Biomaterial Database

Feeding related lateral hypothalamic neuron responses to odors depend on food deprivation in rats. 1988

T Shiraishi

Department of Physiology, Tokai University School of Medicine, Isehara, Japan.

It has been investigated feeding related LHA neuronal activity and responses to odor stimulation in rats at various levels of satiation. Extracellular responses of 168 neurons to three odors, isoamylacetate (AA), cineole (CL), and isovaleric acid (VA), were recorded from 168 LHA neurons of Wistar-SPF male rats. Of 168 units, 107 (63.7%) responded to from one to three odors, but not to light or phonic stimulation. Of the responding units, 94.4% (101/107) were excited, and 5.6% were inhibited. In response to a single electrical stimulation (0.5 msec, 1-10 V) of the OB, 61 units were excited with latencies of 6-43 msec (19.8 +/- 12.0 msec, mean +/- S.D.) indicating compound OB-LHA relations--mono- and polysynaptic through myelinated and nonmyelinated fibers. The results suggest predominantly excitatory effects of both electrical stimulation of the OB and odor stimulation on the LHA. Firing frequency in response to AA or VA was significantly (p less than 0.05) greater for the long fasting group (38 hr, LF, n = 8) than for the NF (nonfasting, n = 12) group; differences between the LF and MF (24 hr, n = 6) groups were not significant. Glucose-sensitive neurons (GSN, n = 19) responded more to odors than non-GSNs (n = 86), and discharge frequency increase depended markedly on food deprivation. Food deprivation results suggest that responsiveness of feeding related LHA neurons to odors depends on the degree of satiation. In conclusion, it was confirmed that olfactory functions are important in the responses of hypothalamic feeding related neurons.

UI	MeSH Term	Description	Entries
D007026	Hypothalamic Area, Lateral	Area in the hypothalamus bounded medially by the mammillothalamic tract and the anterior column of the FORNIX (BRAIN). The medial edge of the INTERNAL CAPSULE and the subthalamic region form its lateral boundary. It contains the lateral hypothalamic nucleus, tuberomammillary nucleus, lateral tuberal nuclei, and fibers of the MEDIAL FOREBRAIN BUNDLE.	Lateral Hypothalamic Area,Lateral Hypothalamic Nucleus,Tuberomammillary Nucleus,Accessory Nucleus of the Ventral Horn,Area Hypothalamica Lateralis,Area Lateralis Hypothalami,Lateral Hypothalamus,Lateral Tuberal Nuclei,Lateral Tuberal Nucleus,Area Hypothalamica Laterali,Area Lateralis Hypothalamus,Area, Lateral Hypothalamic,Areas, Lateral Hypothalamic,Hypothalami, Area Lateralis,Hypothalamic Areas, Lateral,Hypothalamic Nucleus, Lateral,Hypothalamica Laterali, Area,Hypothalamica Lateralis, Area,Hypothalamus, Area Lateralis,Hypothalamus, Lateral,Lateral Hypothalamic Areas,Laterali, Area Hypothalamica,Lateralis Hypothalami, Area,Lateralis Hypothalamus, Area,Lateralis, Area Hypothalamica,Nuclei, Lateral Tuberal,Nucleus, Lateral Hypothalamic,Nucleus, Lateral Tuberal,Nucleus, Tuberomammillary,Tuberal Nuclei, Lateral,Tuberal Nucleus, Lateral
D009474	Neurons	The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.	Nerve Cells,Cell, Nerve,Cells, Nerve,Nerve Cell,Neuron
D001931	Brain Mapping	Imaging techniques used to colocalize sites of brain functions or physiological activity with brain structures.	Brain Electrical Activity Mapping,Functional Cerebral Localization,Topographic Brain Mapping,Brain Mapping, Topographic,Functional Cerebral Localizations,Mapping, Brain,Mapping, Topographic Brain
D004435	Eating	The consumption of edible substances.	Dietary Intake,Feed Intake,Food Intake,Macronutrient Intake,Micronutrient Intake,Nutrient Intake,Nutritional Intake,Ingestion,Dietary Intakes,Feed Intakes,Intake, Dietary,Intake, Feed,Intake, Food,Intake, Macronutrient,Intake, Micronutrient,Intake, Nutrient,Intake, Nutritional,Macronutrient Intakes,Micronutrient Intakes,Nutrient Intakes,Nutritional Intakes
D005508	Food Deprivation	The withholding of food in a structured experimental situation.	Deprivation, Food,Deprivations, Food,Food Deprivations
D006815	Hunger	The desire for FOOD generated by a sensation arising from the lack of food in the STOMACH.
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012903	Smell	The ability to detect scents or odors, such as the function of OLFACTORY RECEPTOR NEURONS.	Olfaction,Sense of Smell,Smell Sense
D013649	Taste	The ability to detect chemicals through gustatory receptors in the mouth, including those on the TONGUE; the PALATE; the PHARYNX; and the EPIGLOTTIS.	Gustation,Taste Sense,Gustations,Sense, Taste,Senses, Taste,Taste Senses,Tastes
D051381	Rats	The common name for the genus Rattus.	Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus