Objective:To investigate the clinical characteristics and the diagnosis and treatment of spontaneous cerebrospinal fluid rhinorrhea with and without empty sella.Method: Retrospective analysis clinical data of 51 patients with spontaneous cerebrospinal fluid rhinorrhea，comparison of non-empty sella syndrome of spontaneous cerebrospinal fluid rhinorrhea with empty sella syndrome of spontaneous cerebrospinal fluid rhinorrhea patients with general characteristics，localization and treatment effect.Result:The incidence of spontaneous cerebrospinal fluid rhinorrhea patients was higher in females than in males，BMI index was higher than the normal value.Of these 51 patients，5 of them were discharged after conservative treatment.Endoscopic sinus surgery was performed in 46 cases，of which 4 cases recurred and all had empty sella syndrome，the success rate of surgical repair was 91.3%.The age of empty sella group，the proportion of high blood pressure and the number of patients with surgical recurrence were significantly higher than those in the non-empty sella group（P<0.05）.The defect locations of two groups were most common in the ethmoid roof，there were no statistically significant differences in each defect location （P＞0.05）. Conclusion:The spontaneous cerebrospinal fluid leak was common in obese middle-aged women，most common defect location in ethmoid roof，nasal endoscopic repair success rate was high，with empty sella surgery were more likely to recur.