Increased Axin expression enhances adult hippocampal neurogenesis and exerts an antidepressant effect. 2019

Wei-Wei Chen, and Wing-Yu Fu, and Yi-Ting Su, and Wei-Qun Fang, and Amy K Y Fu, and Nancy Y Ip
Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.

Major depressive disorders are emerging health problems that affect millions of people worldwide. However, treatment options and targets for drug development are limited. Impaired adult hippocampal neurogenesis is emerging as a key contributor to the pathology of major depressive disorders. We previously demonstrated that increasing the expression of the multifunctional scaffold protein Axis inhibition protein (Axin) by administration of the small molecule XAV939 enhances embryonic neurogenesis and affects social interaction behaviors. This prompted us to examine whether increasing Axin protein level can enhance adult hippocampal neurogenesis and thus contribute to mood regulation. Here, we report that stabilizing Axin increases adult hippocampal neurogenesis and exerts an antidepressant effect. Specifically, treating adult mice with XAV939 increased the amplification of adult neural progenitor cells and neuron production in the hippocampus under both normal and chronic stress conditions. Furthermore, XAV939 injection in mice ameliorated depression-like behaviors induced by chronic restraint stress. Thus, our study demonstrates that Axin/XAV939 plays an important role in adult hippocampal neurogenesis and provides a potential therapeutic approach for mood-related disorders.

UI MeSH Term Description Entries
D008297 Male Males
D008810 Mice, Inbred C57BL One of the first INBRED MOUSE STRAINS to be sequenced. This strain is commonly used as genetic background for transgenic mouse models. Refractory to many tumors, this strain is also preferred model for studying role of genetic variations in development of diseases. Mice, C57BL,Mouse, C57BL,Mouse, Inbred C57BL,C57BL Mice,C57BL Mice, Inbred,C57BL Mouse,C57BL Mouse, Inbred,Inbred C57BL Mice,Inbred C57BL Mouse
D009474 Neurons The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM. Nerve Cells,Cell, Nerve,Cells, Nerve,Nerve Cell,Neuron
D001921 Brain The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM. Encephalon
D002454 Cell Differentiation Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs. Differentiation, Cell,Cell Differentiations,Differentiations, Cell
D003863 Depression Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders. Depressive Symptoms,Emotional Depression,Depression, Emotional,Depressive Symptom,Symptom, Depressive
D003865 Depressive Disorder, Major Disorder in which five (or more) of the following symptoms have been present during the same 2-week period and represent a change from previous functioning; at least one of the symptoms is either (1) depressed mood or (2) loss of interest or pleasure. Symptoms include: depressed mood most of the day, nearly every daily; markedly diminished interest or pleasure in activities most of the day, nearly every day; significant weight loss when not dieting or weight gain; Insomnia or hypersomnia nearly every day; psychomotor agitation or retardation nearly every day; fatigue or loss of energy nearly every day; feelings of worthlessness or excessive or inappropriate guilt; diminished ability to think or concentrate, or indecisiveness, nearly every day; or recurrent thoughts of death, recurrent suicidal ideation without a specific plan, or a suicide attempt. (DSM-5) Depression, Involutional,Major Depressive Disorder,Melancholia, Involutional,Paraphrenia, Involutional,Psychosis, Involutional,Depressive Disorders, Major,Involutional Depression,Involutional Melancholia,Involutional Paraphrenia,Involutional Paraphrenias,Involutional Psychoses,Involutional Psychosis,Major Depressive Disorders,Paraphrenias, Involutional,Psychoses, Involutional
D004195 Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases. Animal Disease Model,Animal Disease Models,Disease Model, Animal
D006575 Heterocyclic Compounds, 3-Ring A class of heterocyclic compounds that include a three-ring fused structure. Both aromatic or non-aromatic ring structures are included in this category. Fused Heterocyclic Compounds, Three-Ring,Heterocyclic Cpds, 3 Ring,Three Ring Heterocyclic Compounds,3-Ring Heterocyclic Compounds,Fused Heterocyclic Compounds, Three Ring,Heterocyclic Compounds, 3 Ring
D006624 Hippocampus A curved elevation of GRAY MATTER extending the entire length of the floor of the TEMPORAL HORN of the LATERAL VENTRICLE (see also TEMPORAL LOBE). The hippocampus proper, subiculum, and DENTATE GYRUS constitute the hippocampal formation. Sometimes authors include the ENTORHINAL CORTEX in the hippocampal formation. Ammon Horn,Cornu Ammonis,Hippocampal Formation,Subiculum,Ammon's Horn,Hippocampus Proper,Ammons Horn,Formation, Hippocampal,Formations, Hippocampal,Hippocampal Formations,Hippocampus Propers,Horn, Ammon,Horn, Ammon's,Proper, Hippocampus,Propers, Hippocampus,Subiculums

Related Publications

Wei-Wei Chen, and Wing-Yu Fu, and Yi-Ting Su, and Wei-Qun Fang, and Amy K Y Fu, and Nancy Y Ip
November 2016, Phytotherapy research : PTR,
Wei-Wei Chen, and Wing-Yu Fu, and Yi-Ting Su, and Wei-Qun Fang, and Amy K Y Fu, and Nancy Y Ip
September 2008, Chemico-biological interactions,
Wei-Wei Chen, and Wing-Yu Fu, and Yi-Ting Su, and Wei-Qun Fang, and Amy K Y Fu, and Nancy Y Ip
May 2013, Annales pharmaceutiques francaises,
Wei-Wei Chen, and Wing-Yu Fu, and Yi-Ting Su, and Wei-Qun Fang, and Amy K Y Fu, and Nancy Y Ip
May 2004, Journal of psychiatry & neuroscience : JPN,
Wei-Wei Chen, and Wing-Yu Fu, and Yi-Ting Su, and Wei-Qun Fang, and Amy K Y Fu, and Nancy Y Ip
January 2023, Journal of advanced research,
Wei-Wei Chen, and Wing-Yu Fu, and Yi-Ting Su, and Wei-Qun Fang, and Amy K Y Fu, and Nancy Y Ip
October 2017, Reviews in the neurosciences,
Wei-Wei Chen, and Wing-Yu Fu, and Yi-Ting Su, and Wei-Qun Fang, and Amy K Y Fu, and Nancy Y Ip
December 2010, Sheng li ke xue jin zhan [Progress in physiology],
Wei-Wei Chen, and Wing-Yu Fu, and Yi-Ting Su, and Wei-Qun Fang, and Amy K Y Fu, and Nancy Y Ip
January 2015, Hippocampus,
Wei-Wei Chen, and Wing-Yu Fu, and Yi-Ting Su, and Wei-Qun Fang, and Amy K Y Fu, and Nancy Y Ip
March 1999, Nature neuroscience,
Wei-Wei Chen, and Wing-Yu Fu, and Yi-Ting Su, and Wei-Qun Fang, and Amy K Y Fu, and Nancy Y Ip
September 2007, Journal of neurochemistry,
Copied contents to your clipboard!