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Our pathogenic pattern, may be summarised in 7 propositions : - psoriasis is a proliferative disease of the epidermis. - the increased mitotic activity is related to imbalance of cyclic nucleotides and of prostaglandins. - this imbalance may be explained by abnormalities of the membranes of the keratinocytes. - this alteration in cell membranes results from immunological phenomena located in psoriatic epidermis. - the disturbance of immunity with production of auto-antibodies may be related to a deficiency in a sub-population of thymus-dependent lymphocytes. - this cyclic deficiency could be due to a viral agent whose penetration and persistence in the body would be dependent upon multiple genetic factors. - numerous external factors may act upon the various steps of this pathogenic chain, to worsen a pre-existent imbalance and precipitate the development of the lesions.
J J Guilhou, and
J Meynadier, and
J Clot
April 1981,
Revue medicale de Bruxelles,
J J Guilhou, and
J Meynadier, and
J Clot
April 1963,
Schweizerische medizinische Wochenschrift,
J J Guilhou, and
J Meynadier, and
J Clot
February 2012,
Autoimmunity,
J J Guilhou, and
J Meynadier, and
J Clot
October 1979,
Ceskoslovenska dermatologie,
J J Guilhou, and
J Meynadier, and
J Clot
January 1981,
Dermatologica,
J J Guilhou, and
J Meynadier, and
J Clot
July 1975,
Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis,
J J Guilhou, and
J Meynadier, and
J Clot
June 1976,
MMW, Munchener medizinische Wochenschrift,
J J Guilhou, and
J Meynadier, and
J Clot
January 1976,
Giornale italiano di cardiologia,
J J Guilhou, and
J Meynadier, and
J Clot
November 1982,
Contraception, fertilite, sexualite,
J J Guilhou, and
J Meynadier, and
J Clot
October 1981,
Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis,
