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We describe a cDNA clone expressing part of p126, a parasitophorous vacuole antigen of Plasmodium falciparum that is processed to smaller fragments about the time of schizont rupture. The amino acid sequence includes determinants that are antigenic during the course of infection. The sequence contains a string of serine residues but no other repetitive elements. Comparison of the sequence to a previously published sequence demonstrates conserved and variable sequence elements. The genomic context of the single copy gene is conserved in six different isolates. p126 is shown to be identical to Pf140, an antigen previously demonstrated to partially protect Saimiri monkeys against P. falciparum infection.
R L Coppel, and
P E Crewther, and
J G Culvenor, and
L H Perrin, and
G V Brown, and
D J Kemp, and
R F Anders
January 1988,
Biology of the cell,
R L Coppel, and
P E Crewther, and
J G Culvenor, and
L H Perrin, and
G V Brown, and
D J Kemp, and
R F Anders
March 1989,
Molecular and biochemical parasitology,
R L Coppel, and
P E Crewther, and
J G Culvenor, and
L H Perrin, and
G V Brown, and
D J Kemp, and
R F Anders
January 1990,
Molecular and biochemical parasitology,
R L Coppel, and
P E Crewther, and
J G Culvenor, and
L H Perrin, and
G V Brown, and
D J Kemp, and
R F Anders
December 1993,
Molecular and biochemical parasitology,
R L Coppel, and
P E Crewther, and
J G Culvenor, and
L H Perrin, and
G V Brown, and
D J Kemp, and
R F Anders
June 2011,
Eukaryotic cell,
R L Coppel, and
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April 1987,
Molecular and biochemical parasitology,
R L Coppel, and
P E Crewther, and
J G Culvenor, and
L H Perrin, and
G V Brown, and
D J Kemp, and
R F Anders
August 1988,
The Journal of biological chemistry,
R L Coppel, and
P E Crewther, and
J G Culvenor, and
L H Perrin, and
G V Brown, and
D J Kemp, and
R F Anders
August 1989,
Journal of immunology (Baltimore, Md. : 1950),
R L Coppel, and
P E Crewther, and
J G Culvenor, and
L H Perrin, and
G V Brown, and
D J Kemp, and
R F Anders
January 1996,
Parasitology research,
R L Coppel, and
P E Crewther, and
J G Culvenor, and
L H Perrin, and
G V Brown, and
D J Kemp, and
R F Anders
April 1988,
Infection and immunity,
