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Alterations in gastric mucosal microvascular endothelium in a stressed condition--relevance to gastric ulcerogenesis. 1988
M Oda, and
M Nakamura, and
K Honda, and
H Komatsu, and
K Kaneko, and
T Azuma, and
M Suematsu, and
Y Yonei, and
N Watanabe, and
M Tsuchiya
Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan.
The present paper describes the morphological and functional alterations of the gastric mucosal microvascular endothelium under restraint-stressed condition. On the basis of the direct cholinergic innervation of capillaries and non-muscular venules in the gastric mucosa, these endothelial changes would be caused by the stress-induced overstimulation of the cholinergic nerves and modified by the degranulation of mast cells, contributing to the stress-induced ulcer formation as schematically illustrated in Fig. 10.
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