-transparent.png){kind=logo}
Normal human placenta secretes within maternal compartment a pregnancy associated protein, placental growth hormone (PGH). This entity, agonist of pituitary GH, appears responsible for the elevated IGF I blood levels observed in the mother during pregnancy, while pituitary GH is no longer secreted. PGH could thus play a significant role in the anabolic processes of pregnancy. The biochemical mechanism responsible for PGH production is the expression of the GH-V gene at the placental level. This has been demonstrated by the positive probing of GH-V mRNA in this tissue, by the establishment of the restriction map and sequence of its cDNA as well as by the NH2-terminal sequence determination of both 22 and 25K PGH forms. The positive aspect of this function for human reproduction gains weight in that a placenta deleted for the CS-A, GH-V and CS-B gene expresses alternative genes coding for protein similar or related to pituitary GH or hPL, respectively.
G Hennen, and
F Frankenne, and
M L Scippo, and
A Igout, and
J Closset, and
G Pirens, and
F Gomez
July 1967,
Science (New York, N.Y.),
G Hennen, and
F Frankenne, and
M L Scippo, and
A Igout, and
J Closset, and
G Pirens, and
F Gomez
October 1979,
American journal of obstetrics and gynecology,
G Hennen, and
F Frankenne, and
M L Scippo, and
A Igout, and
J Closset, and
G Pirens, and
F Gomez
June 1988,
The Journal of clinical endocrinology and metabolism,
G Hennen, and
F Frankenne, and
M L Scippo, and
A Igout, and
J Closset, and
G Pirens, and
F Gomez
April 1998,
Gene,
G Hennen, and
F Frankenne, and
M L Scippo, and
A Igout, and
J Closset, and
G Pirens, and
F Gomez
August 1992,
Pediatric research,
G Hennen, and
F Frankenne, and
M L Scippo, and
A Igout, and
J Closset, and
G Pirens, and
F Gomez
November 1974,
Ugeskrift for laeger,
G Hennen, and
F Frankenne, and
M L Scippo, and
A Igout, and
J Closset, and
G Pirens, and
F Gomez
March 2002,
Biology of reproduction,
G Hennen, and
F Frankenne, and
M L Scippo, and
A Igout, and
J Closset, and
G Pirens, and
F Gomez
September 1982,
The Journal of biological chemistry,
G Hennen, and
F Frankenne, and
M L Scippo, and
A Igout, and
J Closset, and
G Pirens, and
F Gomez
November 1989,
Molecular endocrinology (Baltimore, Md.),
G Hennen, and
F Frankenne, and
M L Scippo, and
A Igout, and
J Closset, and
G Pirens, and
F Gomez
December 1986,
Proceedings of the National Academy of Sciences of the United States of America,
