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Twenty-two consecutive patients with gastroesophageal reflux and erosive or ulcerative esophagitis entered a double-blind, randomized study comparing the effect of 20 mg omeprazole once daily with that of 150 mg ranitidine twice daily on esophageal acidity. Ambulatory 24-h esophageal pH measurements were performed within 1 month before inclusion and after 3 weeks of medication. Omeprazole significantly (p less than 0.05) reduced the number of reflux (pH less than 4) episodes, the number of refluxes lasting greater than 5 min, and the total reflux time. In contrast, ranitidine significantly reduced only the total reflux time. When the two treatment groups were compared, a significant difference in favor of omeprazole was found for daytime and total reflux values, except for the longest reflux and the number of reflux episodes lasting greater than 5 min. Substantial differences, also in favor of omeprazole, were found with regard to the effect on endoscopic healing of the esophagitis.
M Ruth, and
H Enbom, and
L Lundell, and
H Lönroth, and
N Sandberg, and
S Sandmark
June 1991,
Scandinavian journal of gastroenterology,
M Ruth, and
H Enbom, and
L Lundell, and
H Lönroth, and
N Sandberg, and
S Sandmark
November 1990,
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M Ruth, and
H Enbom, and
L Lundell, and
H Lönroth, and
N Sandberg, and
S Sandmark
November 1984,
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M Ruth, and
H Enbom, and
L Lundell, and
H Lönroth, and
N Sandberg, and
S Sandmark
July 1983,
British medical journal (Clinical research ed.),
M Ruth, and
H Enbom, and
L Lundell, and
H Lönroth, and
N Sandberg, and
S Sandmark
November 1983,
British medical journal (Clinical research ed.),
M Ruth, and
H Enbom, and
L Lundell, and
H Lönroth, and
N Sandberg, and
S Sandmark
April 1985,
Digestive diseases and sciences,
M Ruth, and
H Enbom, and
L Lundell, and
H Lönroth, and
N Sandberg, and
S Sandmark
October 1992,
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M Ruth, and
H Enbom, and
L Lundell, and
H Lönroth, and
N Sandberg, and
S Sandmark
March 1986,
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M Ruth, and
H Enbom, and
L Lundell, and
H Lönroth, and
N Sandberg, and
S Sandmark
June 1988,
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M Ruth, and
H Enbom, and
L Lundell, and
H Lönroth, and
N Sandberg, and
S Sandmark
January 1998,
Hepato-gastroenterology,
