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We investigated the effects of stable analogues of prostacyclin (carbacyclin) and thromboxane A2 (U46619) and various calcium antagonists on atherosclerotic cellular indices, intracellular cholesterol content and [3H]thymidine incorporation. Primary culture of human subendothelial cells derived from atherosclerotic plaques of aorta was used. Carbacyclin reduced cholesterol accumulation and cell proliferation. U46619 in opposite to carbacyclin stimulated this processes. In general, carbacyclin exerted a direct antiatherosclerotic and U46619 - atherogenic action in culture. Calcium antagonists: dihydropyridines, verapamil derivatives and diltiazem demonstrated antiatherosclerotic properties themselves and potentiated carbacyclin effect but restricted atherogenicity of U46619.
G N Baldenkov, and
S E Akopov, and
L H Ryong, and
A N Orekhov
July 1983,
The Journal of laboratory and clinical medicine,
G N Baldenkov, and
S E Akopov, and
L H Ryong, and
A N Orekhov
August 1988,
Atherosclerosis,
G N Baldenkov, and
S E Akopov, and
L H Ryong, and
A N Orekhov
December 1980,
Circulation,
G N Baldenkov, and
S E Akopov, and
L H Ryong, and
A N Orekhov
July 1986,
Kardiologiia,
G N Baldenkov, and
S E Akopov, and
L H Ryong, and
A N Orekhov
December 1990,
Clinical and investigative medicine. Medecine clinique et experimentale,
G N Baldenkov, and
S E Akopov, and
L H Ryong, and
A N Orekhov
January 1988,
Arteriosclerosis (Dallas, Tex.),
G N Baldenkov, and
S E Akopov, and
L H Ryong, and
A N Orekhov
February 1998,
Acta paediatrica Japonica : Overseas edition,
G N Baldenkov, and
S E Akopov, and
L H Ryong, and
A N Orekhov
January 2000,
Terapevticheskii arkhiv,
G N Baldenkov, and
S E Akopov, and
L H Ryong, and
A N Orekhov
July 1990,
Zhong xi yi jie he za zhi = Chinese journal of modern developments in traditional medicine,
G N Baldenkov, and
S E Akopov, and
L H Ryong, and
A N Orekhov
January 1980,
Ciba Foundation symposium,
