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The aim of this study was to evaluate the efficacy of human lymphoblastoid interferon (Wellferon) in the treatment of chronic hepatitis B virus (HBV) infection. To date 70 patients have entered the study, 33 randomized to receive interferon at doses of 5 MU/m2 i.m. daily for the first 4 weeks and three times weekly for 5 months thereafter and 31 acted as controls. Seventy-nine per cent of the treated group permanently cleared HBV DNA compared with 48% of the control group (p = 0.01): 69% of the treated patients and 38% of the controls who eliminated HBV DNA cleared HBeAg, HBeAb (p = 0.02). Twenty-four per cent of the treated patients and 3% (p = 0.01) of the control group had clearance of HBsAg and seroconversion to HBsAb. From these results it was concluded that interferon had a therapeutic effect on Italian heterosexual patients with chronic hepatitis B viral replication.
G Mazzella, and
N Villanova, and
M Abdu-Ahmed, and
L Barbara, and
G Saracco, and
M Rizzetto, and
C Cancellieri, and
E Roda
August 1988,
The American journal of medicine,
G Mazzella, and
N Villanova, and
M Abdu-Ahmed, and
L Barbara, and
G Saracco, and
M Rizzetto, and
C Cancellieri, and
E Roda
January 1986,
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G Mazzella, and
N Villanova, and
M Abdu-Ahmed, and
L Barbara, and
G Saracco, and
M Rizzetto, and
C Cancellieri, and
E Roda
September 1989,
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G Mazzella, and
N Villanova, and
M Abdu-Ahmed, and
L Barbara, and
G Saracco, and
M Rizzetto, and
C Cancellieri, and
E Roda
May 1987,
Gut,
G Mazzella, and
N Villanova, and
M Abdu-Ahmed, and
L Barbara, and
G Saracco, and
M Rizzetto, and
C Cancellieri, and
E Roda
January 1986,
Journal of hepatology,
G Mazzella, and
N Villanova, and
M Abdu-Ahmed, and
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G Saracco, and
M Rizzetto, and
C Cancellieri, and
E Roda
January 1989,
BMJ (Clinical research ed.),
G Mazzella, and
N Villanova, and
M Abdu-Ahmed, and
L Barbara, and
G Saracco, and
M Rizzetto, and
C Cancellieri, and
E Roda
November 1989,
Medicina clinica,
G Mazzella, and
N Villanova, and
M Abdu-Ahmed, and
L Barbara, and
G Saracco, and
M Rizzetto, and
C Cancellieri, and
E Roda
April 1992,
Hepatology (Baltimore, Md.),
G Mazzella, and
N Villanova, and
M Abdu-Ahmed, and
L Barbara, and
G Saracco, and
M Rizzetto, and
C Cancellieri, and
E Roda
December 1988,
Chemioterapia : international journal of the Mediterranean Society of Chemotherapy,
G Mazzella, and
N Villanova, and
M Abdu-Ahmed, and
L Barbara, and
G Saracco, and
M Rizzetto, and
C Cancellieri, and
E Roda
January 1995,
The Journal of the Egyptian Public Health Association,
