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Twenty women, who had been randomly selected from women with subclinical hypothyroidism identified in a population study were treated with L-thyroxine and placebo in a double-blind cross-over design during 2 x 6 months. Three women did not complete the study, one because she moved to another part of the country, and two because of nervousness and sense of tachycardia. None of these 'drop-outs' had any objective signs of overtreatment; they had normal pulse rate and a serum T3 concentration within the reference interval. During L-thyroxine treatment serum procollagen-III-peptide concentration increased in 13 women out of the 17 women completing the study and at the end of treatment the mean concentration was significantly raised (P less than 0.001). Serum concentrations of procollagen-III-peptide then correlated with those of free thyroxine (P less than 0.01), total thyroxine (P less than 0.05), and reverse triiodothyronine (P less than 0.05). The same comparison revealed little or no effect on the concentrations of serum creatine kinase activity, transcortin or sex-hormone binding globulin. Heart rate-corrected preejection period and symptom score decreased (P less than 0.05). Four women starting with L-thyroxine showed a marked and prolonged (4-6 months) rise in thyrotrophin concentration during the subsequent placebo period, but remained clinically euthyroid. Four women (of 17) improved during therapy as judged by psychometric testing and their own rating. We could not by pretreatment observations identify these four women apart from serum free and total 3,5,3'-triiodothyronine concentrations in the lower part of the health-associated reference interval. Subclinical hypothyroidism is common among middle-aged and old women, and our findings indicate that approximately one woman in four with this 'subclinical' condition will benefit from L-thyroxine treatment.
E Nyström, and
K Caidahl, and
G Fager, and
C Wikkelsö, and
P A Lundberg, and
G Lindstedt
July 1984,
Annals of internal medicine,
E Nyström, and
K Caidahl, and
G Fager, and
C Wikkelsö, and
P A Lundberg, and
G Lindstedt
April 2002,
The American journal of medicine,
E Nyström, and
K Caidahl, and
G Fager, and
C Wikkelsö, and
P A Lundberg, and
G Lindstedt
October 2003,
Pediatrics international : official journal of the Japan Pediatric Society,
E Nyström, and
K Caidahl, and
G Fager, and
C Wikkelsö, and
P A Lundberg, and
G Lindstedt
May 2012,
Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion,
E Nyström, and
K Caidahl, and
G Fager, and
C Wikkelsö, and
P A Lundberg, and
G Lindstedt
March 1993,
Acta endocrinologica,
E Nyström, and
K Caidahl, and
G Fager, and
C Wikkelsö, and
P A Lundberg, and
G Lindstedt
January 1979,
British medical journal,
E Nyström, and
K Caidahl, and
G Fager, and
C Wikkelsö, and
P A Lundberg, and
G Lindstedt
November 1987,
Pharmacopsychiatry,
E Nyström, and
K Caidahl, and
G Fager, and
C Wikkelsö, and
P A Lundberg, and
G Lindstedt
May 1993,
The Clinical investigator,
E Nyström, and
K Caidahl, and
G Fager, and
C Wikkelsö, and
P A Lundberg, and
G Lindstedt
January 2016,
Advances in clinical and experimental medicine : official organ Wroclaw Medical University,
E Nyström, and
K Caidahl, and
G Fager, and
C Wikkelsö, and
P A Lundberg, and
G Lindstedt
January 1993,
Polski tygodnik lekarski (Warsaw, Poland : 1960),
