BIOMAT Database Logo BIOMAT Database Logo

TRIB3 Promotes the Proliferation and Invasion of Renal Cell Carcinoma Cells via Activating MAPK Signaling Pathway. 2019

Baoan Hong, and Jingcheng Zhou, and Kaifang Ma, and Jiufeng Zhang, and Haibiao Xie, and Kenan Zhang, and Lei Li, and Lin Cai, and Ning Zhang, and Zhongyuan Zhang, and Kan Gong
Department of Urology, Peking University First Hospital, Beijing 100034, P.R. China.

Tribbles pseudokinase 3 (TRIB3) is a member of the mammalian pseudokinase tribbles family and is involved in multiple biological processes. However, the role of TRIB3 in renal cell carcinoma (RCC) remains unclear. In this study, we aimed to elucidate the biological functions of TRIB3 in RCC and explore its underlying mechanisms. TRIB3 expression and its correlation with clinicopathological features was evaluated in 123 patients with RCC. A series of cytological experiments were performed to clarify the biological functions of TRIB3, and potential molecular regulatory mechanisms were explored using transcriptome sequencing. TRIB3 expression was significantly elevated in RCC tissues compared to that in paracancerous tissues, and high expression of TRIB3 was correlated with both advanced tumor stage and unfavorable prognosis. TRIB3 knockdown markedly inhibited RCC cell proliferation, migration and invasion. Furthermore, overexpression of TRIB3 promoted RCC cell proliferation, migration, invasion and xenograft tumor growth. Notably, TRIB3 expression was modulated by hypoxia-inducible factor-1α (HIF-1α), which enhanced cell viability and invasiveness via targeting the MAPK signaling pathway. This study reveals the potential oncogenic role of TRIB3 in RCC pathogenesis and illustrates the mechanisms underlying TRIB3-mediated tumor progression, providing new insight into the development of TRIB3 as a tumor biomarker and therapeutic target.

UI MeSH Term Description Entries
D008297 Male Males
D008807 Mice, Inbred BALB C An inbred strain of mouse that is widely used in IMMUNOLOGY studies and cancer research. BALB C Mice, Inbred,BALB C Mouse, Inbred,Inbred BALB C Mice,Inbred BALB C Mouse,Mice, BALB C,Mouse, BALB C,Mouse, Inbred BALB C,BALB C Mice,BALB C Mouse
D012097 Repressor Proteins Proteins which maintain the transcriptional quiescence of specific GENES or OPERONS. Classical repressor proteins are DNA-binding proteins that are normally bound to the OPERATOR REGION of an operon, or the ENHANCER SEQUENCES of a gene until a signal occurs that causes their release. Repressor Molecules,Transcriptional Silencing Factors,Proteins, Repressor,Silencing Factors, Transcriptional
D002292 Carcinoma, Renal Cell A heterogeneous group of sporadic or hereditary carcinoma derived from cells of the KIDNEYS. There are several subtypes including the clear cells, the papillary, the chromophobe, the collecting duct, the spindle cells (sarcomatoid), or mixed cell-type carcinoma. Adenocarcinoma, Renal Cell,Carcinoma, Hypernephroid,Grawitz Tumor,Hypernephroma,Renal Carcinoma,Adenocarcinoma Of Kidney,Adenocarcinoma, Renal,Chromophil Renal Cell Carcinoma,Chromophobe Renal Cell Carcinoma,Clear Cell Renal Carcinoma,Clear Cell Renal Cell Carcinoma,Collecting Duct Carcinoma,Collecting Duct Carcinoma (Kidney),Collecting Duct Carcinoma of the Kidney,Nephroid Carcinoma,Papillary Renal Cell Carcinoma,Renal Cell Cancer,Renal Cell Carcinoma,Renal Cell Carcinoma, Papillary,Renal Collecting Duct Carcinoma,Sarcomatoid Renal Cell Carcinoma,Adenocarcinoma Of Kidneys,Adenocarcinomas, Renal Cell,Cancer, Renal Cell,Carcinoma, Collecting Duct,Carcinoma, Collecting Duct (Kidney),Carcinoma, Nephroid,Carcinoma, Renal,Carcinomas, Collecting Duct,Carcinomas, Collecting Duct (Kidney),Carcinomas, Renal Cell,Collecting Duct Carcinomas,Collecting Duct Carcinomas (Kidney),Hypernephroid Carcinoma,Hypernephroid Carcinomas,Hypernephromas,Kidney, Adenocarcinoma Of,Nephroid Carcinomas,Renal Adenocarcinoma,Renal Adenocarcinomas,Renal Carcinomas,Renal Cell Adenocarcinoma,Renal Cell Adenocarcinomas,Renal Cell Cancers,Renal Cell Carcinomas,Tumor, Grawitz
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D014945 Wound Healing Restoration of integrity to traumatized tissue. Healing, Wound,Healings, Wound,Wound Healings
D015153 Blotting, Western Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes. Immunoblotting, Western,Western Blotting,Western Immunoblotting,Blot, Western,Immunoblot, Western,Western Blot,Western Immunoblot,Blots, Western,Blottings, Western,Immunoblots, Western,Immunoblottings, Western,Western Blots,Western Blottings,Western Immunoblots,Western Immunoblottings
D015398 Signal Transduction The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway. Cell Signaling,Receptor-Mediated Signal Transduction,Signal Pathways,Receptor Mediated Signal Transduction,Signal Transduction Pathways,Signal Transduction Systems,Pathway, Signal,Pathway, Signal Transduction,Pathways, Signal,Pathways, Signal Transduction,Receptor-Mediated Signal Transductions,Signal Pathway,Signal Transduction Pathway,Signal Transduction System,Signal Transduction, Receptor-Mediated,Signal Transductions,Signal Transductions, Receptor-Mediated,System, Signal Transduction,Systems, Signal Transduction,Transduction, Signal,Transductions, Signal
D015972 Gene Expression Regulation, Neoplastic Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue. Neoplastic Gene Expression Regulation,Regulation of Gene Expression, Neoplastic,Regulation, Gene Expression, Neoplastic

Related Publications

Baoan Hong, and Jingcheng Zhou, and Kaifang Ma, and Jiufeng Zhang, and Haibiao Xie, and Kenan Zhang, and Lei Li, and Lin Cai, and Ning Zhang, and Zhongyuan Zhang, and Kan Gong
TRIB3 promotes oral squamous cell carcinoma cell proliferation by activating the AKT signaling pathway.
April 2021, Experimental and therapeutic medicine,
Baoan Hong, and Jingcheng Zhou, and Kaifang Ma, and Jiufeng Zhang, and Haibiao Xie, and Kenan Zhang, and Lei Li, and Lin Cai, and Ning Zhang, and Zhongyuan Zhang, and Kan Gong
FGF5 promotes osteosarcoma cells proliferation via activating MAPK signaling pathway.
January 2019, Cancer management and research,
Baoan Hong, and Jingcheng Zhou, and Kaifang Ma, and Jiufeng Zhang, and Haibiao Xie, and Kenan Zhang, and Lei Li, and Lin Cai, and Ning Zhang, and Zhongyuan Zhang, and Kan Gong
TRIB3 promotes proliferation, migration, and invasion of retinoblastoma cells by activating the AKT/mTOR signaling pathway.
January 2021, Cancer biomarkers : section A of Disease markers,
Baoan Hong, and Jingcheng Zhou, and Kaifang Ma, and Jiufeng Zhang, and Haibiao Xie, and Kenan Zhang, and Lei Li, and Lin Cai, and Ning Zhang, and Zhongyuan Zhang, and Kan Gong
Gαi1 Promoted Proliferation, Migration and Invasion via Activating the Akt-mTOR/Erk-MAPK Signaling Pathway in Renal Cell Carcinoma.
January 2021, OncoTargets and therapy,
Baoan Hong, and Jingcheng Zhou, and Kaifang Ma, and Jiufeng Zhang, and Haibiao Xie, and Kenan Zhang, and Lei Li, and Lin Cai, and Ning Zhang, and Zhongyuan Zhang, and Kan Gong
SKA2 promotes proliferation and invasion of hepatocellular carcinoma cells via activating the β-catenin signaling pathway.
July 2020, Neoplasma,
Baoan Hong, and Jingcheng Zhou, and Kaifang Ma, and Jiufeng Zhang, and Haibiao Xie, and Kenan Zhang, and Lei Li, and Lin Cai, and Ning Zhang, and Zhongyuan Zhang, and Kan Gong
RRS1 Promotes Retinoblastoma Cell Proliferation and Invasion via Activating the AKT/mTOR Signaling Pathway.
January 2020, BioMed research international,
Baoan Hong, and Jingcheng Zhou, and Kaifang Ma, and Jiufeng Zhang, and Haibiao Xie, and Kenan Zhang, and Lei Li, and Lin Cai, and Ning Zhang, and Zhongyuan Zhang, and Kan Gong
Nucleophosmin promotes lung adenocarcinoma cell proliferation, migration and invasion by activating the EGFR/MAPK signaling pathway.
June 2023, Oncology reports,
Baoan Hong, and Jingcheng Zhou, and Kaifang Ma, and Jiufeng Zhang, and Haibiao Xie, and Kenan Zhang, and Lei Li, and Lin Cai, and Ning Zhang, and Zhongyuan Zhang, and Kan Gong
S100A9 promotes the proliferation and invasion of HepG2 hepatocellular carcinoma cells via the activation of the MAPK signaling pathway.
March 2013, International journal of oncology,
Baoan Hong, and Jingcheng Zhou, and Kaifang Ma, and Jiufeng Zhang, and Haibiao Xie, and Kenan Zhang, and Lei Li, and Lin Cai, and Ning Zhang, and Zhongyuan Zhang, and Kan Gong
GATA1 promotes colorectal cancer cell proliferation, migration and invasion via activating AKT signaling pathway.
July 2019, Molecular and cellular biochemistry,
Baoan Hong, and Jingcheng Zhou, and Kaifang Ma, and Jiufeng Zhang, and Haibiao Xie, and Kenan Zhang, and Lei Li, and Lin Cai, and Ning Zhang, and Zhongyuan Zhang, and Kan Gong
[Corrigendum] S100A9 promotes the proliferation and invasion of HepG2 hepatocellular carcinoma cells via the activation of the MAPK signaling pathway.
April 2023, International journal of oncology,
Copied contents to your clipboard!