Biomaterial Database

Efficacy of Azole Antifungal in Treatment of Pityriasis Versicolor. 2019

Van Tran Cam, and Thuong Nguyen Van, and Khang Tran Hau, and Doanh Le Huu, and Phuong Pham Thi Minh, and Sau Nguyen Huu, and Thu Nguyen Minh, and Marco Gandolfi, and Francesca Satolli, and Claudio Feliciani, and Michael Tirant, and Aleksandra Vojvodic, and Torello Lotti

National Hospital of Dermatology and Venereology, Hanoi, Vietnam.

OBJECTIVE Compare itraconazole alone, fluconazole combined with ketoconazole and ketoconazole in the treatment of patients with pityriasis versicolor. METHODS A group of 240 pityriasis versicolor patients (confirmed with KOH and culture) were classified into 3 groups: Fluconazole 300 mg a week and 2% ketoconazole foam twice a week for 2 weeks (Category I), Itraconazole 200 mg daily for one week (category II); Ketoconazole 2% foam daily for 2 weeks (Category 3). Clinical (colour of macule, scale, pruritus) and mycological assessment were done after 4 weeks of therapy. RESULTS After 4 weeks of treatment, clinical cure was observed in 62.4% (Category I), 36.3% (Category II) and 37.5% (Category III). CONCLUSIONS It was reported in our study that the most effective regimen for PV patients is fluconazole 300 mg per week combined with ketoconazole 2% twice a week for 2 weeks.