-transparent.png){kind=logo}
We investigated the mechanism(s) by which MHC-restricted suppressor T cells (Ts) induced by i.v. injection of allogeneic DNP-modified lymphoid cells (alloinduced Ts) suppress the DNFB contact sensitivity response. It was shown that alloinduced Ts acted only during the early phases (afferent limb) of sensitization. They were incapable of suppressing previously sensitized recipients or of inhibiting the expression of DNFB-immune LN cells when co-transferred into normal recipients. The target of alloinduced Ts seems to be cell proliferation, i.e., inhibition of antigen-induced cell proliferation (DNA synthesis) in Ts recipient mice. The failure of recipients of alloinduced Ts to generate DNFB-immune LN cells capable of transferring contact sensitivity to normal recipients also suggests that these Ts act by preventing the development of an expanded clone of mature immune T cells. The suppressive effects of alloinduced Ts also were inhibited by prior in vitro treatment with anti-TNP serum. The data are discussed in terms of current models of suppression, and are compared to mechanisms of suppression in other contact sensitivity models.
S D Miller, and
M S Sy, and
H N Claman
February 1991,
Cellular immunology,
S D Miller, and
M S Sy, and
H N Claman
September 1976,
Journal of immunology (Baltimore, Md. : 1950),
S D Miller, and
M S Sy, and
H N Claman
November 1986,
Immunology letters,
S D Miller, and
M S Sy, and
H N Claman
November 1983,
Journal of the American Academy of Dermatology,
S D Miller, and
M S Sy, and
H N Claman
April 1988,
Infection and immunity,
S D Miller, and
M S Sy, and
H N Claman
March 1985,
Immunology,
S D Miller, and
M S Sy, and
H N Claman
April 1986,
Cellular immunology,
S D Miller, and
M S Sy, and
H N Claman
April 1989,
Clinical immunology and immunopathology,
S D Miller, and
M S Sy, and
H N Claman
January 1981,
Archives of dermatological research,
S D Miller, and
M S Sy, and
H N Claman
April 2005,
Nature immunology,
