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Depressed patients in general practice were included in a double-blind placebo-controlled six-week trial of amitriptyline (median dose 125 mg). The patients were relatively mildly ill and satisfied diagnostic criteria for depression and treatment with antidepressants in routine practice. Amitriptyline was found to be considerably superior to placebo after six weeks and significantly so as early as two weeks after the start of treatment. The effects of the antidepressant were on the core symptoms of depression, and were apparent in all but the most mildly ill patients. The findings suggest that tricyclic antidepressants are of considerable therapeutic benefit to depressed patients in general practice.
J A Hollyman, and
P Freeling, and
E S Paykel, and
A Bhat, and
P Sedgwick
January 1988,
Neuropsychobiology,
J A Hollyman, and
P Freeling, and
E S Paykel, and
A Bhat, and
P Sedgwick
August 1984,
Journal of clinical psychopharmacology,
J A Hollyman, and
P Freeling, and
E S Paykel, and
A Bhat, and
P Sedgwick
January 1991,
The British journal of clinical practice,
J A Hollyman, and
P Freeling, and
E S Paykel, and
A Bhat, and
P Sedgwick
June 1991,
Fortschritte der Medizin,
J A Hollyman, and
P Freeling, and
E S Paykel, and
A Bhat, and
P Sedgwick
January 1978,
The Practitioner,
J A Hollyman, and
P Freeling, and
E S Paykel, and
A Bhat, and
P Sedgwick
August 1997,
Archives of general psychiatry,
J A Hollyman, and
P Freeling, and
E S Paykel, and
A Bhat, and
P Sedgwick
June 1995,
The American journal of psychiatry,
J A Hollyman, and
P Freeling, and
E S Paykel, and
A Bhat, and
P Sedgwick
January 1994,
International clinical psychopharmacology,
J A Hollyman, and
P Freeling, and
E S Paykel, and
A Bhat, and
P Sedgwick
January 1993,
Scandinavian journal of gastroenterology. Supplement,
J A Hollyman, and
P Freeling, and
E S Paykel, and
A Bhat, and
P Sedgwick
May 1982,
Pharmacopsychiatria,
