-transparent.png){kind=logo}
Gene expression may occur in unexpected ectopic sites when diverse genetic elements are juxtaposed as chimeric genes in transgenic mice. To determine the specific contribution of the promoter and reporter gene in ectopic expression, we have analyzed the expression of 14 different fusion genes in transgenic mice. Chimeric genes containing the mouse metallothionein-I promoter linked to either the rat or human growth hormone gene or the calcitonin/CGRP gene are expressed in a very similar pattern of neuronal regions. This ectopic expression is not a unique feature of the metallothionein promoter, since transferring the human growth hormone gene to four other heterologous promoters resulted in varying degrees of ectopic expression in overlapping subsets of cortical and hypothalamic neurons. The novel pattern of ectopic expression suggests that these otherwise unrelated neurons share a common developmental regulatory machinery for activation of gene transcription.
A F Russo, and
E B Crenshaw, and
S A Lira, and
D M Simmons, and
L W Swanson, and
M G Rosenfeld
January 1991,
Current studies in hematology and blood transfusion,
A F Russo, and
E B Crenshaw, and
S A Lira, and
D M Simmons, and
L W Swanson, and
M G Rosenfeld
August 1990,
The Journal of biological chemistry,
A F Russo, and
E B Crenshaw, and
S A Lira, and
D M Simmons, and
L W Swanson, and
M G Rosenfeld
April 1992,
Plant cell reports,
A F Russo, and
E B Crenshaw, and
S A Lira, and
D M Simmons, and
L W Swanson, and
M G Rosenfeld
August 1992,
Protein science : a publication of the Protein Society,
A F Russo, and
E B Crenshaw, and
S A Lira, and
D M Simmons, and
L W Swanson, and
M G Rosenfeld
February 1993,
Developmental biology,
A F Russo, and
E B Crenshaw, and
S A Lira, and
D M Simmons, and
L W Swanson, and
M G Rosenfeld
May 1991,
Plant molecular biology,
A F Russo, and
E B Crenshaw, and
S A Lira, and
D M Simmons, and
L W Swanson, and
M G Rosenfeld
January 1985,
Banbury report,
A F Russo, and
E B Crenshaw, and
S A Lira, and
D M Simmons, and
L W Swanson, and
M G Rosenfeld
November 1988,
Cell differentiation and development : the official journal of the International Society of Developmental Biologists,
A F Russo, and
E B Crenshaw, and
S A Lira, and
D M Simmons, and
L W Swanson, and
M G Rosenfeld
January 1987,
Progress in brain research,
A F Russo, and
E B Crenshaw, and
S A Lira, and
D M Simmons, and
L W Swanson, and
M G Rosenfeld
February 1991,
Neuron,
