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Treatment with either pentamidine isethionate or trimethoprim-sulfamethoxazole significantly reduces the mortality of Pneumocystis carinii pneumonia. It is not known whether a combination might act in an additive, synergistic, or antagonistic manner. We studied the interaction of these two agents in the steroid-conditioned rat model of pneumocystosis. Of animals receiving pentamidine alone, 48% died and 45% had P. carinii cysts at autopsy. Trimethoprim-sulfamethoxazole alone resulted in 21% mortality, and cysts were found in 28%. Both agents in full doses resulted in 45% deaths and cysts in 37%. Animals treated with half-dosages of pentamidine plus trimethroprim-sulfamethoxazole had mortality of 35%, and 21% had cysts. Trimethoprim alone, in two dosages, was ineffective in eradicating P. carinii cysts. The data suggest that combination therapy is no more effective than trimethoprim-sulfamethoxazole alone in the treatment of P. carinii pneumonia.
R M Kluge, and
D M Spaulding, and
A J Spain
March 1987,
Annals of internal medicine,
R M Kluge, and
D M Spaulding, and
A J Spain
June 1981,
The American journal of medicine,
R M Kluge, and
D M Spaulding, and
A J Spain
December 1979,
Southern medical journal,
R M Kluge, and
D M Spaulding, and
A J Spain
March 1989,
Klinische Wochenschrift,
R M Kluge, and
D M Spaulding, and
A J Spain
February 1978,
The Journal of pediatrics,
R M Kluge, and
D M Spaulding, and
A J Spain
January 1996,
Pharmacotherapy,
R M Kluge, and
D M Spaulding, and
A J Spain
September 1991,
DICP : the annals of pharmacotherapy,
R M Kluge, and
D M Spaulding, and
A J Spain
August 1991,
AIDS (London, England),
R M Kluge, and
D M Spaulding, and
A J Spain
November 1966,
Pediatrics,
R M Kluge, and
D M Spaulding, and
A J Spain
September 1976,
The New England journal of medicine,
