-transparent.png){kind=logo}
The activities of aryl hydrocarbon hydroxylase and 7-ethoxycoumarin O-de-ethylase in the rat submandibular gland, both of which are normally very low, were increased about 10- and 25-fold, respectively, by administration of 3-methylcholanthrene. The increased activity of aryl hydrocarbon hydroxylase was inhibited by 7,8-benzoflavone but little if any by metyrapone and SKF-525A. The submandibular gland aryl hydrocarbon hydroxylase was also inhibited by antibodies elicited against rat liver cytochrome P-448 and NADPH-cytochrome P-450 reductase, respectively, and slightly by anti-cytochrome b 5 antibody, suggesting that submandibular gland aryl hydrocarbon hydroxylase resembles that of the liver, not only in the immunochemical properties of cytochrome P-450 involved, but also in the entire enzyme complex, including the electron transferring system. Cofactor(s) required by aryl hydrocarbon hydroxylase in submandibular gland was NADPH, whereas NADH sustained the reaction at a much slower rate (about 20%). NADH showed some additive action when added with NADPH.
K Murakami, and
T Ishikawa, and
T Shimosato, and
M Noshiro, and
S Hayashi, and
K Okuda
June 1986,
Hiroshima Daigaku shigaku zasshi. The Journal of Hiroshima University Dental Society,
K Murakami, and
T Ishikawa, and
T Shimosato, and
M Noshiro, and
S Hayashi, and
K Okuda
December 1980,
The Journal of pharmacology and experimental therapeutics,
K Murakami, and
T Ishikawa, and
T Shimosato, and
M Noshiro, and
S Hayashi, and
K Okuda
March 1981,
The British journal of dermatology,
K Murakami, and
T Ishikawa, and
T Shimosato, and
M Noshiro, and
S Hayashi, and
K Okuda
January 1994,
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine,
K Murakami, and
T Ishikawa, and
T Shimosato, and
M Noshiro, and
S Hayashi, and
K Okuda
June 1983,
Biochemical pharmacology,
K Murakami, and
T Ishikawa, and
T Shimosato, and
M Noshiro, and
S Hayashi, and
K Okuda
July 1981,
Cancer research,
K Murakami, and
T Ishikawa, and
T Shimosato, and
M Noshiro, and
S Hayashi, and
K Okuda
January 1981,
Drug metabolism and disposition: the biological fate of chemicals,
K Murakami, and
T Ishikawa, and
T Shimosato, and
M Noshiro, and
S Hayashi, and
K Okuda
July 1981,
Biochemical pharmacology,
K Murakami, and
T Ishikawa, and
T Shimosato, and
M Noshiro, and
S Hayashi, and
K Okuda
February 1979,
Lancet (London, England),
K Murakami, and
T Ishikawa, and
T Shimosato, and
M Noshiro, and
S Hayashi, and
K Okuda
September 1983,
British journal of clinical pharmacology,
