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Lymphocyte subpopulations from patients with myasthenia gravis were evaluated during chronic steroid therapy. A marked lymphocytopenia (10-70%) was initially (day 3-21) noticed as well as a preferential depletion of thymus-derived cells which paralleled the clinical deterioration. Thus there was a relative increase in B cells, although their absolute number remained rather constant. These changes were reverted within 2-4 weeks in spite of continuous treatment. These findings are compatible with a release of myasthenic factors (anti-acetylcholine receptor antibodies?) during the initial steroid-induced cell damage, the long-term beneficial effects being due to loss or suppression of autoreactive helper t cells.
L Hammarström, and
E Smith
July 1983,
Neurology,
L Hammarström, and
E Smith
September 1978,
Nihon Kyobu Shikkan Gakkai zasshi,
L Hammarström, and
E Smith
February 1982,
Journal of neurology, neurosurgery, and psychiatry,
L Hammarström, and
E Smith
July 1980,
Clinical and experimental immunology,
L Hammarström, and
E Smith
October 1976,
Neurology,
L Hammarström, and
E Smith
January 1979,
Journal of neurology, neurosurgery, and psychiatry,
L Hammarström, and
E Smith
December 2006,
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia,
L Hammarström, and
E Smith
August 1979,
Journal of neurology, neurosurgery, and psychiatry,
L Hammarström, and
E Smith
August 1983,
Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry,
L Hammarström, and
E Smith
February 1992,
Rinsho shinkeigaku = Clinical neurology,
