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The antianginal effects of nifedipine 20 mg three times a day and atenolol 100 mg once a day singly and in combination were investigated in 16 patients with angina pectoris. The amount of work that could be done before angina and ST depression appeared was significantly increased by atenolol and the combination but not by nifedipine. At peak exercise the number of leads on a 16 point precordial electrocardiogram map that demonstrated greater than or equal to 1 mm ST segment depression was significantly reduced from a mean (SD) of 5.0 (0.4) on placebo to 3.7 (0.6), 2.8 (0.4), and 2.3 (0.7) on nifedipine, atenolol, and the combination respectively. Mean resting left ventricular ejection fraction, assessed by gated radionuclide ventriculography, did not change during any active treatment phase but increased significantly during exercise only on nifedipine and the combination. The nifedipine/atenolol combination was the most effective treatment, and the data suggest that nifedipine may be used to best advantage in combination with a beta blocker.
I N Findlay, and
K MacLeod, and
M Ford, and
G Gillen, and
A T Elliott, and
H J Dargie
January 1988,
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I N Findlay, and
K MacLeod, and
M Ford, and
G Gillen, and
A T Elliott, and
H J Dargie
July 1989,
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I N Findlay, and
K MacLeod, and
M Ford, and
G Gillen, and
A T Elliott, and
H J Dargie
October 1993,
European heart journal,
I N Findlay, and
K MacLeod, and
M Ford, and
G Gillen, and
A T Elliott, and
H J Dargie
June 1983,
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I N Findlay, and
K MacLeod, and
M Ford, and
G Gillen, and
A T Elliott, and
H J Dargie
October 1986,
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I N Findlay, and
K MacLeod, and
M Ford, and
G Gillen, and
A T Elliott, and
H J Dargie
December 1987,
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I N Findlay, and
K MacLeod, and
M Ford, and
G Gillen, and
A T Elliott, and
H J Dargie
November 1989,
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I N Findlay, and
K MacLeod, and
M Ford, and
G Gillen, and
A T Elliott, and
H J Dargie
September 1983,
Zhonghua xin xue guan bing za zhi,
I N Findlay, and
K MacLeod, and
M Ford, and
G Gillen, and
A T Elliott, and
H J Dargie
December 1979,
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I N Findlay, and
K MacLeod, and
M Ford, and
G Gillen, and
A T Elliott, and
H J Dargie
January 1977,
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