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Dietary administration of 5% sodium citrate to male F344 rats clearly promoted the induction of preneoplastic and neoplastic lesions of the bladder initiated with N-butyl-N-(4-hydroxybutyl)nitrosamine. Enhancement of tumorigenesis by sodium citrate was associated with changes in a number of urinary parameters: apparent elevation of pH; increase of sodium ion concentration; increase of crystalline MgNH4PO4. These results show that sodium citrate promotes bladder carcinogenesis.
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