BIOMAT Database Logo BIOMAT Database Logo

PHENOTYPIC CHARACTERISTICS OF CHORIONIC VILLI DURING GESTATIONAL TROPHOBLASTIC DISEASES. 2019

N Chikvaidze, and N Kintraia, and T Muzashvili, and M Gachechiladze, and G Burkadze
Tbilisi State Medical University, Georgia.

Differential diagnosis of gestational trophoblastic diseases (GTP) using standard micromorphological examination is complicated and less reliable. Therefore, the aim of our study was to investigate the immunohistochemical phenotype of chorionic villi during GTP, as well as in physiological cases. Study included five groups: I group - normal chorionic villi, II group - chorionic villi with hydropic changes, III group - Partial mole, IV group - Complete mole, V group - early Complete mole. Following markers were examined using standard immunohistochemistry: CK7, CK20, P63, PLAP, P57, CK5, CK8/18, CEA, CD34 Ki67, P53, E-cadherin, vimentin, β-catenin and inhibin. Study results showed that chorionic villi are characterized with marked phenotypic heterogeneity in normal tissue, as well as in cases of GTP, which can be used as an additional criterion for the differential diagnosis of GTP.

UI MeSH Term Description Entries
D007150 Immunohistochemistry Histochemical localization of immunoreactive substances using labeled antibodies as reagents. Immunocytochemistry,Immunogold Techniques,Immunogold-Silver Techniques,Immunohistocytochemistry,Immunolabeling Techniques,Immunogold Technics,Immunogold-Silver Technics,Immunolabeling Technics,Immunogold Silver Technics,Immunogold Silver Techniques,Immunogold Technic,Immunogold Technique,Immunogold-Silver Technic,Immunogold-Silver Technique,Immunolabeling Technic,Immunolabeling Technique,Technic, Immunogold,Technic, Immunogold-Silver,Technic, Immunolabeling,Technics, Immunogold,Technics, Immunogold-Silver,Technics, Immunolabeling,Technique, Immunogold,Technique, Immunogold-Silver,Technique, Immunolabeling,Techniques, Immunogold,Techniques, Immunogold-Silver,Techniques, Immunolabeling
D010641 Phenotype The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment. Phenotypes
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D002824 Chorionic Villi Threadlike vascular projections of the chorion. Chorionic villi may be free or embedded within the DECIDUA forming the site for exchange of substances between fetal and maternal blood (PLACENTA). Placental Villi,Labyrinth of the Placenta,Labyrinthine Placenta,Placental Labyrinth Layer,Chorionic Villus,Labyrinth Layer, Placental,Placental Labyrinth Layers,Placental Villus,Villi, Chorionic,Villi, Placental,Villus, Chorionic,Villus, Placental
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D006828 Hydatidiform Mole Trophoblastic hyperplasia associated with normal gestation, or molar pregnancy. It is characterized by the swelling of the CHORIONIC VILLI and elevated human CHORIONIC GONADOTROPIN. Hydatidiform moles or molar pregnancy may be categorized as complete or partial based on their gross morphology, histopathology, and karyotype. Molar Pregnancy,Pregnancy, Molar,Hydatid Mole,Hydatidiform Mole, Complete,Hydatidiform Mole, Partial,Complete Hydatidiform Mole,Complete Hydatidiform Moles,Hydatid Moles,Hydatidiform Moles,Hydatidiform Moles, Complete,Hydatidiform Moles, Partial,Molar Pregnancies,Mole, Complete Hydatidiform,Mole, Hydatid,Mole, Hydatidiform,Mole, Partial Hydatidiform,Moles, Complete Hydatidiform,Moles, Hydatid,Moles, Hydatidiform,Moles, Partial Hydatidiform,Partial Hydatidiform Mole,Partial Hydatidiform Moles,Pregnancies, Molar
D014594 Uterine Neoplasms Tumors or cancer of the UTERUS. Cancer of Uterus,Uterine Cancer,Cancer of the Uterus,Neoplasms, Uterine,Neoplasms, Uterus,Uterus Cancer,Uterus Neoplasms,Cancer, Uterine,Cancer, Uterus,Cancers, Uterine,Cancers, Uterus,Neoplasm, Uterine,Neoplasm, Uterus,Uterine Cancers,Uterine Neoplasm,Uterus Cancers,Uterus Neoplasm
D031901 Gestational Trophoblastic Disease A group of diseases arising from pregnancy that are commonly associated with hyperplasia of trophoblasts (TROPHOBLAST) and markedly elevated human CHORIONIC GONADOTROPIN. They include HYDATIDIFORM MOLE, invasive mole (HYDATIDIFORM MOLE, INVASIVE), placental-site trophoblastic tumor (TROPHOBLASTIC TUMOR, PLACENTAL SITE), and CHORIOCARCINOMA. These neoplasms have varying propensities for invasion and spread. Gestational Trophoblastic Neoplasms,Trophoblastic Neoplasms, Gestational,Gestational Trophoblastic Neoplasia,Disease, Gestational Trophoblastic,Diseases, Gestational Trophoblastic,Gestational Trophoblastic Diseases,Gestational Trophoblastic Neoplasm,Neoplasia, Gestational Trophoblastic,Neoplasm, Gestational Trophoblastic,Neoplasms, Gestational Trophoblastic,Trophoblastic Disease, Gestational,Trophoblastic Diseases, Gestational,Trophoblastic Neoplasia, Gestational,Trophoblastic Neoplasm, Gestational

Related Publications

N Chikvaidze, and N Kintraia, and T Muzashvili, and M Gachechiladze, and G Burkadze
Comparison of telomerase activity in normal chorionic villi to trophoblastic diseases.
January 1998, International journal of oncology,
N Chikvaidze, and N Kintraia, and T Muzashvili, and M Gachechiladze, and G Burkadze
Gestational trophoblastic diseases.
October 2003, International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics,
N Chikvaidze, and N Kintraia, and T Muzashvili, and M Gachechiladze, and G Burkadze
Gestational trophoblastic diseases.
February 1996, Current opinion in obstetrics & gynecology,
N Chikvaidze, and N Kintraia, and T Muzashvili, and M Gachechiladze, and G Burkadze
Gestational trophoblastic diseases.
October 1989, Seminars in oncology,
N Chikvaidze, and N Kintraia, and T Muzashvili, and M Gachechiladze, and G Burkadze
Gestational trophoblastic diseases.
August 2008, The Journal of reproductive medicine,
N Chikvaidze, and N Kintraia, and T Muzashvili, and M Gachechiladze, and G Burkadze
[Gestational trophoblastic diseases].
January 1994, Annales de pathologie,
N Chikvaidze, and N Kintraia, and T Muzashvili, and M Gachechiladze, and G Burkadze
Gestational trophoblastic diseases.
January 2001, Journal of epidemiology and biostatistics,
N Chikvaidze, and N Kintraia, and T Muzashvili, and M Gachechiladze, and G Burkadze
Gestational trophoblastic diseases: 3. Human chorionic gonadotropin-free beta-subunit, a reliable marker of placental site trophoblastic tumors.
August 2006, Gynecologic oncology,
N Chikvaidze, and N Kintraia, and T Muzashvili, and M Gachechiladze, and G Burkadze
Gestational trophoblastic disease and human chorionic gonadotropin measurement.
September 1987, The Journal of reproductive medicine,
N Chikvaidze, and N Kintraia, and T Muzashvili, and M Gachechiladze, and G Burkadze
Pathology of gestational trophoblastic diseases.
December 2003, Best practice & research. Clinical obstetrics & gynaecology,
Copied contents to your clipboard!