BIOMAT Database Logo BIOMAT Database Logo

Molecular biology of the HLA class I and class II genes. 1986

C T Wake

The human major histocompatibility complex (the HLA complex) encodes two classes of cell surface heterodimeric glycoproteins which regulate the immune response to foreign antigens. Molecular analysis of the HLA class I and class II genes has yielded considerable information about their organization and structure. The class I genes consist of the polymorphic A, B and C genes and the non-polymorphic Qa, Tla-like genes. The HLA class II region contains multiple alpha and beta genes and pseudogenes which map into three subregions: DR, DQ and DP. The class II genes share similar gene structures, but vary in their degree of polymorphism.

UI MeSH Term Description Entries
D008040 Genetic Linkage The co-inheritance of two or more non-allelic GENES due to their being located more or less closely on the same CHROMOSOME. Genetic Linkage Analysis,Linkage, Genetic,Analyses, Genetic Linkage,Analysis, Genetic Linkage,Genetic Linkage Analyses,Linkage Analyses, Genetic,Linkage Analysis, Genetic
D011110 Polymorphism, Genetic The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level. Gene Polymorphism,Genetic Polymorphism,Polymorphism (Genetics),Genetic Polymorphisms,Gene Polymorphisms,Polymorphism, Gene,Polymorphisms (Genetics),Polymorphisms, Gene,Polymorphisms, Genetic
D002874 Chromosome Mapping Any method used for determining the location of and relative distances between genes on a chromosome. Gene Mapping,Linkage Mapping,Genome Mapping,Chromosome Mappings,Gene Mappings,Genome Mappings,Linkage Mappings,Mapping, Chromosome,Mapping, Gene,Mapping, Genome,Mapping, Linkage,Mappings, Chromosome,Mappings, Gene,Mappings, Genome,Mappings, Linkage
D005786 Gene Expression Regulation Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation. Gene Action Regulation,Regulation of Gene Expression,Expression Regulation, Gene,Regulation, Gene Action,Regulation, Gene Expression
D005802 Genes, MHC Class II Genetic loci in the vertebrate major histocompatibility complex that encode polymorphic products which control the immune response to specific antigens. The genes are found in the HLA-D region in humans and include H-2M, I-A, and I-E loci in mice. Class II Genes,Genes, Class II,Genes, HLA Class II,MHC Class II Genes,Class II Gene,Gene, Class II
D006680 HLA Antigens Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases. Human Leukocyte Antigen,Human Leukocyte Antigens,Leukocyte Antigens,HL-A Antigens,Antigen, Human Leukocyte,Antigens, HL-A,Antigens, HLA,Antigens, Human Leukocyte,Antigens, Leukocyte,HL A Antigens,Leukocyte Antigen, Human,Leukocyte Antigens, Human
D006682 HLA-DP Antigens A group of the D-related HLA antigens (human) found to differ from the DR antigens in genetic locus and therefore inheritance. These antigens are polymorphic glycoproteins comprising alpha and beta chains and are found on lymphoid and other cells, often associated with certain diseases. HLA-PL Antigens,HLA-SB Antigens,HLA-DP,HLA-PL,HLA-SB,Antigens, HLA-DP,Antigens, HLA-PL,Antigens, HLA-SB,HLA DP Antigens,HLA PL Antigens,HLA SB Antigens
D006683 HLA-DQ Antigens A group of the D-related HLA antigens found to differ from the DR antigens in genetic locus and therefore inheritance. These antigens are polymorphic glycoproteins comprising alpha and beta chains and are found on lymphoid and other cells, often associated with certain diseases. HLA-DC Antigens,HLA-MB Antigens,HLA-DC,HLA-DQ,HLA-DS,HLA-DS Antigens,HLA-LB,HLA-LB Antigens,HLA-MB,Antigens, HLA-DC,Antigens, HLA-DQ,Antigens, HLA-DS,Antigens, HLA-LB,Antigens, HLA-MB,HLA DC Antigens,HLA DQ Antigens,HLA DS Antigens,HLA LB Antigens,HLA MB Antigens
D006684 HLA-DR Antigens A subclass of HLA-D antigens that consist of alpha and beta chains. The inheritance of HLA-DR antigens differs from that of the HLA-DQ ANTIGENS and HLA-DP ANTIGENS. HLA-DR,Antigens, HLA-DR,HLA DR Antigens
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

C T Wake
Molecular analysis of HLA Class I and Class II genes in four indigenous Malaysian populations.
February 2010, Tissue antigens,
C T Wake
HLA Class I and Class II Genes Distribution of the Iranian Sistanis.
June 2018, Iranian journal of immunology : IJI,
C T Wake
Molecular biology of murine MHC class II genes.
January 1991, Critical reviews in immunology,
C T Wake
[Identification of HLA class II polymorphism with molecular biology techniques].
October 1991, Lakartidningen,
C T Wake
Molecular analysis of HLA Class I and Class II genes in five different South Indian linguistic groups.
May 2021, HLA,
C T Wake
Molecular analysis of HLA class II genes in Goodpasture's disease.
February 1995, QJM : monthly journal of the Association of Physicians,
C T Wake
Molecular typing of HLA class I and class II for a transplantation programme.
December 1998, Bone marrow transplantation,
C T Wake
Molecular biology of class II genes in man: an introduction.
September 1983, Human immunology,
C T Wake
Polymorphism and evolution of HLA class I and II genes and molecules.
January 1999, Reviews in immunogenetics,
C T Wake
Molecular analysis of HLA class I (HLA-A and -B) and HLA class II (HLA-DRB1) genes in Japanese patients with multiple sclerosis (Western type and Asian type).
December 1998, Tissue antigens,
Copied contents to your clipboard!