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Multiwalled Carbon Nanotubes for Dental Applications. 2019

Petros Kechagioglou, and Eleftherios Andriotis, and Petros Papagerakis, and Silvana Papagerakis
Department of Surgery, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada. petros.kechagioglou@usask.ca.

Multiwalled carbon nanotubes (MWCNTs) are a particularly promising drug delivery system due to their high surface area allowing high-protein loading, their stability under biological conditions, and their unique interaction with cellular membranes. Studies have shown that covalent attachment of polyethylene glycol (PEG) improves biocompatibility and enhances surface hydrophilicity properties, suggesting that PEGylated MWCNTs are efficient and toxic-safe drug delivery systems. So far, CNTs are used for a broad range of applications in dentistry, especially for dental tissue repair and restorative. Here we present a protocol of protein immobilization onto MWCNTs and describe the procedure for delivering them into the cells after characterization of the nanotubes.

UI MeSH Term Description Entries
D011092 Polyethylene Glycols Polymers of ETHYLENE OXIDE and water, and their ethers. They vary in consistency from liquid to solid depending on the molecular weight indicated by a number following the name. They are used as SURFACTANTS, dispersing agents, solvents, ointment and suppository bases, vehicles, and tablet excipients. Some specific groups are NONOXYNOLS, OCTOXYNOLS, and POLOXAMERS. Macrogols,Polyoxyethylenes,Carbowax,Macrogol,Polyethylene Glycol,Polyethylene Oxide,Polyethyleneoxide,Polyglycol,Glycol, Polyethylene,Glycols, Polyethylene,Oxide, Polyethylene,Oxides, Polyethylene,Polyethylene Oxides,Polyethyleneoxides,Polyglycols,Polyoxyethylene
D011506 Proteins Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein. Gene Products, Protein,Gene Proteins,Protein,Protein Gene Products,Proteins, Gene
D000078483 Regenerative Endodontics A dental specialty concerned with biologically-based procedures designed to physiologically replace damaged tooth structures, including dentin and root structures, as well as cells of the pulp-dentin complex. Endodontic, Regenerative,Endodontics, Regenerative,Regenerative Endodontic
D016503 Drug Delivery Systems Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity. Drug Targeting,Delivery System, Drug,Delivery Systems, Drug,Drug Delivery System,Drug Targetings,System, Drug Delivery,Systems, Drug Delivery,Targeting, Drug,Targetings, Drug
D037742 Nanotubes, Carbon Nanometer-sized tubes composed mainly of CARBON. Such nanotubes are used as probes for high-resolution structural and chemical imaging of biomolecules with ATOMIC FORCE MICROSCOPY. Buckytubes,Carbon Nanotubes,Nanoribbons,Buckytube,Carbon Nanotube,Nanoribbon,Nanotube, Carbon

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