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Expression of interleukin 2 (IL-2) receptor (Tac antigen) on leukemic cells from 4 patients with acute lymphocytic leukemia (ALL) and 3 patients with blastic crisis of chronic myelogenous leukemia (CML-BC) was examined. Cells from 6 out of 7 patients did not carry immunoglobulins on their surfaces, but reacted with monoclonal antibodies (mAb) detecting B-cell related antigens such as B1, OKB2 and Leu12. Cells from two cases expressed Tac antigen immediately after cell separation. Phorbol 12-myristate 13-acetate (PMA) could induce Tac antigen in all cases. SDS-PAGE analysis of immunoprecipitates by anti-Tac mAb demonstrated that the molecular weight of Tac antigen on most of the leukemic cells was similar to that of Tac antigen present on Con A-stimulated normal lymphocytes. These leukemic cells poorly responded to exogenous recombinant IL-2. These findings suggest that IL-2 may interact with the immature and mature B cells, and play an important role in the differentiation of B lymphocytes.
M Matsuoka, and
T Hattori, and
F Kawano, and
T Ishii, and
T Uchiyama, and
K Takatsuki
August 1984,
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M Matsuoka, and
T Hattori, and
F Kawano, and
T Ishii, and
T Uchiyama, and
K Takatsuki
August 1984,
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M Matsuoka, and
T Hattori, and
F Kawano, and
T Ishii, and
T Uchiyama, and
K Takatsuki
August 1986,
Clinical and experimental immunology,
M Matsuoka, and
T Hattori, and
F Kawano, and
T Ishii, and
T Uchiyama, and
K Takatsuki
May 1985,
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M Matsuoka, and
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K Takatsuki
January 1985,
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M Matsuoka, and
T Hattori, and
F Kawano, and
T Ishii, and
T Uchiyama, and
K Takatsuki
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M Matsuoka, and
T Hattori, and
F Kawano, and
T Ishii, and
T Uchiyama, and
K Takatsuki
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Leukemia,
M Matsuoka, and
T Hattori, and
F Kawano, and
T Ishii, and
T Uchiyama, and
K Takatsuki
October 1987,
Blood,
M Matsuoka, and
T Hattori, and
F Kawano, and
T Ishii, and
T Uchiyama, and
K Takatsuki
August 1987,
Tissue antigens,
M Matsuoka, and
T Hattori, and
F Kawano, and
T Ishii, and
T Uchiyama, and
K Takatsuki
January 1998,
Polskie Archiwum Medycyny Wewnetrznej,
