Genome analysis of a Bacillus subtilis strain reveals genetic mutations determining biocontrol properties. 2019

Bettina Bóka, and László Manczinger, and Sándor Kocsubé, and Kadaikunnan Shine, and Naiyf S Alharbi, and Jamal M Khaled, and Martin Münsterkötter, and Csaba Vágvölgyi, and László Kredics
Department of Microbiology, Faculty of Science and Informatics, University of Szeged, Közép fasor 52, Szeged, 6726, Hungary.

Several Bacillus strains are used as biocontrol agents, as they frequently have strong antagonistic effects against microbial plant pathogens. Bacillus strain SZMC 6179J, isolated from tomato rhizosphere, was previously shown to have excellent in vitro antagonistic properties against the most important fungal pathogens of tomato (Alternaria solani, Botrytis cinerea, Phytophthora infestans and Sclerotinia sclerotiorum) as well as several Fusarium species. Taxonomic investigations revealed that it is a member of the B. subtilis subsp. subtilis group and very closely related with the reference type strain B. subtilis subsp. subtilis 168. The sequenced genome of strain SZMC 6179J contains the genes responsible for the synthesis of the extracellular antibiotics surfactin, fengycin and bacilysin. Compared to strain 168, a prophage-like region is missing from the genome of SZMC 6179J, while there are 106 single nucleotide polymorphisms and 23 deletion-insertion polymorphisms. The high biocontrol potential of strain SZMC 6179J may results from a single base deletion in the sfp gene encoding the transcription factor of the surfactin and fengycin operons. Hypermutated regions reflecting short-time evolutionary processes could be detected in SZMC 6179J. The deletion-insertion polymorphism in the sfp gene and the detected hypermutations can be suggested as genetic determinants of biocontrol features in B. subtilis.

UI MeSH Term Description Entries
D009154 Mutation Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. Mutations
D010456 Peptides, Cyclic Peptides whose amino acid residues are linked together forming a circular chain. Some of them are ANTI-INFECTIVE AGENTS; some are biosynthesized non-ribosomally (PEPTIDE BIOSYNTHESIS, NON-RIBOSOMAL). Circular Peptide,Cyclic Peptide,Cyclic Peptides,Cyclopeptide,Orbitide,Circular Peptides,Cyclopeptides,Orbitides,Peptide, Circular,Peptide, Cyclic,Peptides, Circular
D010802 Phylogeny The relationships of groups of organisms as reflected by their genetic makeup. Community Phylogenetics,Molecular Phylogenetics,Phylogenetic Analyses,Phylogenetic Analysis,Phylogenetic Clustering,Phylogenetic Comparative Analysis,Phylogenetic Comparative Methods,Phylogenetic Distance,Phylogenetic Generalized Least Squares,Phylogenetic Groups,Phylogenetic Incongruence,Phylogenetic Inference,Phylogenetic Networks,Phylogenetic Reconstruction,Phylogenetic Relatedness,Phylogenetic Relationships,Phylogenetic Signal,Phylogenetic Structure,Phylogenetic Tree,Phylogenetic Trees,Phylogenomics,Analyse, Phylogenetic,Analysis, Phylogenetic,Analysis, Phylogenetic Comparative,Clustering, Phylogenetic,Community Phylogenetic,Comparative Analysis, Phylogenetic,Comparative Method, Phylogenetic,Distance, Phylogenetic,Group, Phylogenetic,Incongruence, Phylogenetic,Inference, Phylogenetic,Method, Phylogenetic Comparative,Molecular Phylogenetic,Network, Phylogenetic,Phylogenetic Analyse,Phylogenetic Clusterings,Phylogenetic Comparative Analyses,Phylogenetic Comparative Method,Phylogenetic Distances,Phylogenetic Group,Phylogenetic Incongruences,Phylogenetic Inferences,Phylogenetic Network,Phylogenetic Reconstructions,Phylogenetic Relatednesses,Phylogenetic Relationship,Phylogenetic Signals,Phylogenetic Structures,Phylogenetic, Community,Phylogenetic, Molecular,Phylogenies,Phylogenomic,Reconstruction, Phylogenetic,Relatedness, Phylogenetic,Relationship, Phylogenetic,Signal, Phylogenetic,Structure, Phylogenetic,Tree, Phylogenetic
D010935 Plant Diseases Diseases of plants. Disease, Plant,Diseases, Plant,Plant Disease
D004151 Dipeptides Peptides composed of two amino acid units. Dipeptide
D005658 Fungi A kingdom of eukaryotic, heterotrophic organisms that live parasitically as saprobes, including MUSHROOMS; YEASTS; smuts, molds, etc. They reproduce either sexually or asexually, and have life cycles that range from simple to complex. Filamentous fungi, commonly known as molds, refer to those that grow as multicellular colonies. Fungi, Filamentous,Molds,Filamentous Fungi,Filamentous Fungus,Fungus,Fungus, Filamentous,Mold
D005798 Genes, Bacterial The functional hereditary units of BACTERIA. Bacterial Gene,Bacterial Genes,Gene, Bacterial
D005810 Multigene Family A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed) Gene Clusters,Genes, Reiterated,Cluster, Gene,Clusters, Gene,Families, Multigene,Family, Multigene,Gene Cluster,Gene, Reiterated,Multigene Families,Reiterated Gene,Reiterated Genes
D000073336 Whole Genome Sequencing Techniques to determine the entire sequence of the GENOME of an organism or individual. Complete Genome Sequencing,Genome Sequencing, Complete,Genome Sequencing, Whole,Sequencing, Complete Genome,Sequencing, Whole Genome
D000595 Amino Acid Sequence The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION. Protein Structure, Primary,Amino Acid Sequences,Sequence, Amino Acid,Sequences, Amino Acid,Primary Protein Structure,Primary Protein Structures,Protein Structures, Primary,Structure, Primary Protein,Structures, Primary Protein

Related Publications

Bettina Bóka, and László Manczinger, and Sándor Kocsubé, and Kadaikunnan Shine, and Naiyf S Alharbi, and Jamal M Khaled, and Martin Münsterkötter, and Csaba Vágvölgyi, and László Kredics
April 2023, Marine genomics,
Bettina Bóka, and László Manczinger, and Sándor Kocsubé, and Kadaikunnan Shine, and Naiyf S Alharbi, and Jamal M Khaled, and Martin Münsterkötter, and Csaba Vágvölgyi, and László Kredics
November 2012, Journal of bacteriology,
Bettina Bóka, and László Manczinger, and Sándor Kocsubé, and Kadaikunnan Shine, and Naiyf S Alharbi, and Jamal M Khaled, and Martin Münsterkötter, and Csaba Vágvölgyi, and László Kredics
December 1966, Journal of bacteriology,
Bettina Bóka, and László Manczinger, and Sándor Kocsubé, and Kadaikunnan Shine, and Naiyf S Alharbi, and Jamal M Khaled, and Martin Münsterkötter, and Csaba Vágvölgyi, and László Kredics
August 2022, International journal of molecular sciences,
Bettina Bóka, and László Manczinger, and Sándor Kocsubé, and Kadaikunnan Shine, and Naiyf S Alharbi, and Jamal M Khaled, and Martin Münsterkötter, and Csaba Vágvölgyi, and László Kredics
January 2013, Genome announcements,
Bettina Bóka, and László Manczinger, and Sándor Kocsubé, and Kadaikunnan Shine, and Naiyf S Alharbi, and Jamal M Khaled, and Martin Münsterkötter, and Csaba Vágvölgyi, and László Kredics
July 2018, Metabolic engineering,
Bettina Bóka, and László Manczinger, and Sándor Kocsubé, and Kadaikunnan Shine, and Naiyf S Alharbi, and Jamal M Khaled, and Martin Münsterkötter, and Csaba Vágvölgyi, and László Kredics
June 1973, Canadian journal of microbiology,
Bettina Bóka, and László Manczinger, and Sándor Kocsubé, and Kadaikunnan Shine, and Naiyf S Alharbi, and Jamal M Khaled, and Martin Münsterkötter, and Csaba Vágvölgyi, and László Kredics
June 2017, Genome announcements,
Bettina Bóka, and László Manczinger, and Sándor Kocsubé, and Kadaikunnan Shine, and Naiyf S Alharbi, and Jamal M Khaled, and Martin Münsterkötter, and Csaba Vágvölgyi, and László Kredics
July 2016, Genome announcements,
Bettina Bóka, and László Manczinger, and Sándor Kocsubé, and Kadaikunnan Shine, and Naiyf S Alharbi, and Jamal M Khaled, and Martin Münsterkötter, and Csaba Vágvölgyi, and László Kredics
March 2015, Genome announcements,
Copied contents to your clipboard!