Ethical, legal and operational issues of artificial intelligence. Mastering the ethical issues associated with artificial intelligence healthcare without curbing its diffusion source of innovations and advances for our health system: this is the meaning of the idea of «positive regulation» of AI in healthcare This article presents the ethical, legal and operational issues associated with this approach at the heart of the Ethik-IA initiative. It shows that the answers to be provided are first and foremost recommendations of good practice, as in the case of the prototype of the standard of good practice of AI applied to genomic data developed with the teams of the Imagine University Hospital Institute.