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Plasticity of synaptic structure and function play an essential role in neuronal development, cognitive functions, and degenerative diseases. Recently, low-intensity pulsed ultrasound (LIPUS) stimulation has been reported as a promising technology for neuromodulation. However, the effect of LIPUS stimulation on the structural and functional synaptic plasticity in rat hippocampus has not yet been addressed. The aim of this study was to investigate whether LIPUS stimulation could affect the dendritic structure, electrophysiological properties, and expression level of glutamate receptors GluN2A, GluN2B, and GluR1 subunits in rat hippocampus. Transcranial LIPUS was delivered to CA1 of the intact hippocampus of rats ( n = 40 ) for 10 days (10 min/day) with the following parameters: fundamental frequency of 0.5 MHz, pulse repetition frequency (PRF) of 500 Hz, peak negative pressure of 0.42 MPa, and Ispta of 360 mW/cm2. The effect of LIPUS on dendritic structure, electrophysiological properties, and the expression of neurotransmitter receptors was measured using Golgi staining, electrophysiological recording, and western blotting, respectively. Golgi staining and electrophysiological recordings showed that LIPUS stimulation significantly increased the density of dendritic spines (0.72 ± 0.17 versus 0.94 ± 0.19 spines/ [Formula: see text], ) and the frequency of spontaneous excitatory postsynaptic current (0.37 ± 0.14 versus 1.77 ± 0.37 Hz, ) of CA1 hippocampal neurons. Furthermore, the western blotting analysis demonstrated a significant increase in the expression level of GluN2A ( ). The results illustrated the effect of LIPUS on the dendritic structure, function, and neurotransmitter receptors, which may provide a powerful tool for treating neurodegenerative diseases.
Xiaowei Huang, and
Zhengrong Lin, and
Kaiyue Wang, and
Xiufang Liu, and
Wei Zhou, and
Long Meng, and
Jiqing Huang, and
Kexin Yuan, and
Lili Niu, and
Hairong Zheng
January 2022,
Brain stimulation,
Xiaowei Huang, and
Zhengrong Lin, and
Kaiyue Wang, and
Xiufang Liu, and
Wei Zhou, and
Long Meng, and
Jiqing Huang, and
Kexin Yuan, and
Lili Niu, and
Hairong Zheng
October 1998,
Hormones and behavior,
Xiaowei Huang, and
Zhengrong Lin, and
Kaiyue Wang, and
Xiufang Liu, and
Wei Zhou, and
Long Meng, and
Jiqing Huang, and
Kexin Yuan, and
Lili Niu, and
Hairong Zheng
March 2019,
Physiological research,
Xiaowei Huang, and
Zhengrong Lin, and
Kaiyue Wang, and
Xiufang Liu, and
Wei Zhou, and
Long Meng, and
Jiqing Huang, and
Kexin Yuan, and
Lili Niu, and
Hairong Zheng
July 1989,
Experimental neurology,
Xiaowei Huang, and
Zhengrong Lin, and
Kaiyue Wang, and
Xiufang Liu, and
Wei Zhou, and
Long Meng, and
Jiqing Huang, and
Kexin Yuan, and
Lili Niu, and
Hairong Zheng
July 2019,
Neuroscience,
Xiaowei Huang, and
Zhengrong Lin, and
Kaiyue Wang, and
Xiufang Liu, and
Wei Zhou, and
Long Meng, and
Jiqing Huang, and
Kexin Yuan, and
Lili Niu, and
Hairong Zheng
April 2009,
Indian journal of orthopaedics,
Xiaowei Huang, and
Zhengrong Lin, and
Kaiyue Wang, and
Xiufang Liu, and
Wei Zhou, and
Long Meng, and
Jiqing Huang, and
Kexin Yuan, and
Lili Niu, and
Hairong Zheng
January 2022,
Frontiers in cellular neuroscience,
Xiaowei Huang, and
Zhengrong Lin, and
Kaiyue Wang, and
Xiufang Liu, and
Wei Zhou, and
Long Meng, and
Jiqing Huang, and
Kexin Yuan, and
Lili Niu, and
Hairong Zheng
August 2023,
BMC neuroscience,
Xiaowei Huang, and
Zhengrong Lin, and
Kaiyue Wang, and
Xiufang Liu, and
Wei Zhou, and
Long Meng, and
Jiqing Huang, and
Kexin Yuan, and
Lili Niu, and
Hairong Zheng
December 2008,
The Journal of neuroscience : the official journal of the Society for Neuroscience,
Xiaowei Huang, and
Zhengrong Lin, and
Kaiyue Wang, and
Xiufang Liu, and
Wei Zhou, and
Long Meng, and
Jiqing Huang, and
Kexin Yuan, and
Lili Niu, and
Hairong Zheng
August 2008,
Experimental neurology,
