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The paper reports on a 6-year-old boy with precocious pseudopuberty due to androgen hypersecretion by a testicular interstitial cell tumour. Steroidogenesis, characterized by high testosterone, dihydrotestosterone, androstenedione, dehydroepiandrosterone and 17-hydroxyprogesterone plasma levels, was not modified by ACTH, dexamethasone or HCG administration. Gonadotropins were subnormal and unresponsive to LRH stimulation. TSH and prolactin levels were normal both in basal and dynamic conditions. The hormonal profile progressively returned to prepubertal value and persisted normal for 6 months after removal of the tumour. The patient entered puberty spontaneously at 7,6/12 years showing a normal pubertal basal and LRH stimulated FSH and LH and a pubertal circadian rhythm of both gonadotropins and testosterone.
T Criscuolo, and
A A Sinisi, and
L Perrone, and
M Graziani, and
A Bellastella, and
M Faggiano
January 2010,
Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology,
T Criscuolo, and
A A Sinisi, and
L Perrone, and
M Graziani, and
A Bellastella, and
M Faggiano
March 1984,
The Journal of clinical endocrinology and metabolism,
T Criscuolo, and
A A Sinisi, and
L Perrone, and
M Graziani, and
A Bellastella, and
M Faggiano
May 1989,
Anales espanoles de pediatria,
T Criscuolo, and
A A Sinisi, and
L Perrone, and
M Graziani, and
A Bellastella, and
M Faggiano
March 1985,
Recenti progressi in medicina,
T Criscuolo, and
A A Sinisi, and
L Perrone, and
M Graziani, and
A Bellastella, and
M Faggiano
March 2012,
Medicina clinica,
T Criscuolo, and
A A Sinisi, and
L Perrone, and
M Graziani, and
A Bellastella, and
M Faggiano
December 1984,
Anales espanoles de pediatria,
T Criscuolo, and
A A Sinisi, and
L Perrone, and
M Graziani, and
A Bellastella, and
M Faggiano
April 2004,
Gynecologie, obstetrique & fertilite,
T Criscuolo, and
A A Sinisi, and
L Perrone, and
M Graziani, and
A Bellastella, and
M Faggiano
March 1970,
Revista argentina de endocrinologia y metabolismo,
T Criscuolo, and
A A Sinisi, and
L Perrone, and
M Graziani, and
A Bellastella, and
M Faggiano
February 1978,
Obstetrics and gynecology,
T Criscuolo, and
A A Sinisi, and
L Perrone, and
M Graziani, and
A Bellastella, and
M Faggiano
December 2019,
Cureus,
