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The objectives of this study were to investigate the bactericidal activity in serum of cefotaxime alone or in combination with tobramycin against clinical strains and to determine the influence of tobramycin on the pharmacokinetics of cefotaxime. The peak bactericidal activity in serum of cefotaxime alone against Klebsiella oxytoca, Enterobacter aerogenes, Serratia marcescens, Pseudomonas cepacia, and Listeria monocytogenes varied between 1:4 and 1:256. Bactericidal activity could still be detected at 6 h against K. oxytoca and L. monocytogenes. The addition of tobramycin increased the bactericidal activity of cefotaxime against E. aerogenes from 1:16 to 1:128 (P less than 0.01). Cefotaxime recovery from urine was significantly decreased when tobramycin was added. Our data are comparable with those of other investigators who have shown a limited increase in the bactericidal activity of cefotaxime when aminoglycosides are added.
M G Bergeron, and
M LeBel, and
A Charest, and
J F Forcier, and
J Morin, and
F Vallée
April 1989,
Pathologie-biologie,
M G Bergeron, and
M LeBel, and
A Charest, and
J F Forcier, and
J Morin, and
F Vallée
October 1991,
Antimicrobial agents and chemotherapy,
M G Bergeron, and
M LeBel, and
A Charest, and
J F Forcier, and
J Morin, and
F Vallée
October 1981,
Antimicrobial agents and chemotherapy,
M G Bergeron, and
M LeBel, and
A Charest, and
J F Forcier, and
J Morin, and
F Vallée
January 1984,
Infection,
M G Bergeron, and
M LeBel, and
A Charest, and
J F Forcier, and
J Morin, and
F Vallée
May 1990,
Pathologie-biologie,
M G Bergeron, and
M LeBel, and
A Charest, and
J F Forcier, and
J Morin, and
F Vallée
December 1986,
Antimicrobial agents and chemotherapy,
M G Bergeron, and
M LeBel, and
A Charest, and
J F Forcier, and
J Morin, and
F Vallée
February 1986,
Antimicrobial agents and chemotherapy,
M G Bergeron, and
M LeBel, and
A Charest, and
J F Forcier, and
J Morin, and
F Vallée
January 1982,
Reviews of infectious diseases,
M G Bergeron, and
M LeBel, and
A Charest, and
J F Forcier, and
J Morin, and
F Vallée
June 1989,
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology,
M G Bergeron, and
M LeBel, and
A Charest, and
J F Forcier, and
J Morin, and
F Vallée
July 1987,
Antimicrobial agents and chemotherapy,
