BIOMAT Database Logo BIOMAT Database Logo

Low-Dose Total Body Irradiation Can Enhance Systemic Immune Related Response Induced by Hypo-Fractionated Radiation. 2019

Jing Liu, and Jie Zhou, and Min Wu, and ChuanFei Hu, and Juan Yang, and Dong Li, and Peng Wu, and Yue Chen, and Ping Chen, and Sheng Lin, and YongXia Cui, and ShaoZhi Fu, and JingBo Wu
Department of Oncology, The Affiliated Hospital of Southwest Medical University, Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, China.

A systemic immune related response (SIME) of radiotherapy has been occasionally observed on metastatic tumors, but the clinical outcomes remain poor. Novel treatment approaches are therefore needed to improve SIME ratio. We used a combination of hypo-fractionated radiation therapy (H-RT) with low-dose total body irradiation (L-TBI) in a syngeneic mouse model of breast and colon carcinoma. The combination therapy of H-RT and L-TBI potentially enhanced SIME by infiltration of CD8+ T cell and altering the immunosuppressive microenvironment in non-irradiated subcutaneous tumor lesions. The frequency of IFN-γ, as a tumor-specific CD8+ T cells producing, significantly inhibited the secondary tumor growth of breast and colon. Our findings suggest that L-TBI could serve as a potential therapeutic agent for metastatic breast and colon cancer and, together with H-RT, their therapeutic potential is enhanced significantly.

UI MeSH Term Description Entries
D007371 Interferon-gamma The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES. Interferon Type II,Interferon, Immune,gamma-Interferon,Interferon, gamma,Type II Interferon,Immune Interferon,Interferon, Type II
D008325 Mammary Neoplasms, Experimental Experimentally induced mammary neoplasms in animals to provide a model for studying human BREAST NEOPLASMS. Experimental Mammary Neoplasms,Neoplasms, Experimental Mammary,Experimental Mammary Neoplasm,Mammary Neoplasm, Experimental,Neoplasm, Experimental Mammary
D008807 Mice, Inbred BALB C An inbred strain of mouse that is widely used in IMMUNOLOGY studies and cancer research. BALB C Mice, Inbred,BALB C Mouse, Inbred,Inbred BALB C Mice,Inbred BALB C Mouse,Mice, BALB C,Mouse, BALB C,Mouse, Inbred BALB C,BALB C Mice,BALB C Mouse
D003110 Colonic Neoplasms Tumors or cancer of the COLON. Cancer of Colon,Colon Adenocarcinoma,Colon Cancer,Cancer of the Colon,Colon Neoplasms,Colonic Cancer,Neoplasms, Colonic,Adenocarcinoma, Colon,Adenocarcinomas, Colon,Cancer, Colon,Cancer, Colonic,Cancers, Colon,Cancers, Colonic,Colon Adenocarcinomas,Colon Cancers,Colon Neoplasm,Colonic Cancers,Colonic Neoplasm,Neoplasm, Colon,Neoplasm, Colonic,Neoplasms, Colon
D005260 Female Females
D000069473 Radiation Dose Hypofractionation A treatment schedule in which the total dose of radiation is divided into large doses but fewer exposure times. Hypofractionated Dose, Radiation,Radiotherapy Dose Hypofractionation,Radiotherapy Minibeams,Dose Hypofractionation, Radiation,Dose Hypofractionation, Radiotherapy,Hypofractionation, Radiation Dose,Hypofractionation, Radiotherapy Dose,Hypofractionations, Radiotherapy Dose,Minibeam, Radiotherapy,Radiation Hypofractionated Dose,Radiotherapy Minibeam
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D014916 Whole-Body Irradiation Irradiation of the whole body with ionizing or non-ionizing radiation. It is applicable to humans or animals but not to microorganisms. Radiation, Whole-Body,Total Body Irradiation,Irradiation, Total Body,Irradiation, Whole-Body,Whole-Body Radiation,Irradiation, Whole Body,Irradiations, Total Body,Irradiations, Whole-Body,Radiation, Whole Body,Radiations, Whole-Body,Total Body Irradiations,Whole Body Irradiation,Whole Body Radiation,Whole-Body Irradiations,Whole-Body Radiations
D045744 Cell Line, Tumor A cell line derived from cultured tumor cells. Tumor Cell Line,Cell Lines, Tumor,Line, Tumor Cell,Lines, Tumor Cell,Tumor Cell Lines
D059016 Tumor Microenvironment The milieu surrounding neoplasms consisting of cells, vessels, soluble factors, and molecules, that can influence and be influenced by, the neoplasm's growth. Cancer Microenvironment,Cancer Microenvironments,Microenvironment, Cancer,Microenvironment, Tumor,Microenvironments, Cancer,Microenvironments, Tumor,Tumor Microenvironments

Related Publications

Jing Liu, and Jie Zhou, and Min Wu, and ChuanFei Hu, and Juan Yang, and Dong Li, and Peng Wu, and Yue Chen, and Ping Chen, and Sheng Lin, and YongXia Cui, and ShaoZhi Fu, and JingBo Wu
Low-dose total-body γ irradiation modulates immune response to acute proton radiation.
March 2012, Radiation research,
Jing Liu, and Jie Zhou, and Min Wu, and ChuanFei Hu, and Juan Yang, and Dong Li, and Peng Wu, and Yue Chen, and Ping Chen, and Sheng Lin, and YongXia Cui, and ShaoZhi Fu, and JingBo Wu
Low-dose total body irradiation enhances systemic anti-tumor immunity induced by local cryotherapy.
September 2023, Journal of cancer research and clinical oncology,
Jing Liu, and Jie Zhou, and Min Wu, and ChuanFei Hu, and Juan Yang, and Dong Li, and Peng Wu, and Yue Chen, and Ping Chen, and Sheng Lin, and YongXia Cui, and ShaoZhi Fu, and JingBo Wu
[RADIATION-INDUCED LEUKEMIA IN WISTAR RATS AFTER FRACTIONATED TOTAL-BODY IRRADIATION].
December 1963, Blut,
Jing Liu, and Jie Zhou, and Min Wu, and ChuanFei Hu, and Juan Yang, and Dong Li, and Peng Wu, and Yue Chen, and Ping Chen, and Sheng Lin, and YongXia Cui, and ShaoZhi Fu, and JingBo Wu
Effect of triple therapy with low-dose total body irradiation and hypo-fractionated radiation plus anti-programmed cell death protein 1 blockade on abscopal antitumor immune responses in breast cancer.
April 2023, International immunopharmacology,
Jing Liu, and Jie Zhou, and Min Wu, and ChuanFei Hu, and Juan Yang, and Dong Li, and Peng Wu, and Yue Chen, and Ping Chen, and Sheng Lin, and YongXia Cui, and ShaoZhi Fu, and JingBo Wu
Low dose total-body irradiation.
January 1988, The British journal of radiology,
Jing Liu, and Jie Zhou, and Min Wu, and ChuanFei Hu, and Juan Yang, and Dong Li, and Peng Wu, and Yue Chen, and Ping Chen, and Sheng Lin, and YongXia Cui, and ShaoZhi Fu, and JingBo Wu
Fractionated total-body irradiation.
April 1976, Cancer,
Jing Liu, and Jie Zhou, and Min Wu, and ChuanFei Hu, and Juan Yang, and Dong Li, and Peng Wu, and Yue Chen, and Ping Chen, and Sheng Lin, and YongXia Cui, and ShaoZhi Fu, and JingBo Wu
Low-dose total body irradiation facilitates antitumoral Th1 immune responses.
January 2021, Theranostics,
Jing Liu, and Jie Zhou, and Min Wu, and ChuanFei Hu, and Juan Yang, and Dong Li, and Peng Wu, and Yue Chen, and Ping Chen, and Sheng Lin, and YongXia Cui, and ShaoZhi Fu, and JingBo Wu
Effects of low-dose radiation on the immune system of mice after total-body irradiation.
October 2010, Radiation research,
Jing Liu, and Jie Zhou, and Min Wu, and ChuanFei Hu, and Juan Yang, and Dong Li, and Peng Wu, and Yue Chen, and Ping Chen, and Sheng Lin, and YongXia Cui, and ShaoZhi Fu, and JingBo Wu
[Antitumor effects by low dose total body irradiation].
October 2006, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan,
Jing Liu, and Jie Zhou, and Min Wu, and ChuanFei Hu, and Juan Yang, and Dong Li, and Peng Wu, and Yue Chen, and Ping Chen, and Sheng Lin, and YongXia Cui, and ShaoZhi Fu, and JingBo Wu
Radiation Sensitization of Leukemic Cells for Low Dose Total Body Irradiation.
April 2015, EBioMedicine,
Copied contents to your clipboard!