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Three patients with Paget's disease of bone were treated by disodium etidronate (EHDP) without interruption during periods of 18 to 30 months. In one case the daily dose was also unduly high (approximately equal to 18 mg/kg/day). A moderate to conspicuous diminution of the renal function was observed in all cases. The three patients developed skeletal pain in a gradual but progressively severe pattern. Seven nontraumatic fractures in nonpagetic bones were encountered. EHDP produces blockage of bone mineralization and excessive suppression of bone remodeling, therefore increasing the risks of fracture. EHDP affects not only pagetic bones but normal skeleton. A baseline evaluation of the renal function might help to identify those patients with greater risk to develop skeletal side effects during EHDP treatment.
C Mautalen, and
D Gonzalez, and
E L Blumenfeld, and
E Santini Araujo, and
F Schajowicz
January 1983,
Clinical orthopaedics and related research,
C Mautalen, and
D Gonzalez, and
E L Blumenfeld, and
E Santini Araujo, and
F Schajowicz
January 1984,
Revue du rhumatisme et des maladies osteo-articulaires,
C Mautalen, and
D Gonzalez, and
E L Blumenfeld, and
E Santini Araujo, and
F Schajowicz
May 1985,
Revue medicale de Liege,
C Mautalen, and
D Gonzalez, and
E L Blumenfeld, and
E Santini Araujo, and
F Schajowicz
November 1976,
Schweizerische medizinische Wochenschrift,
C Mautalen, and
D Gonzalez, and
E L Blumenfeld, and
E Santini Araujo, and
F Schajowicz
September 1978,
The Medical letter on drugs and therapeutics,
C Mautalen, and
D Gonzalez, and
E L Blumenfeld, and
E Santini Araujo, and
F Schajowicz
December 1988,
Clinical rheumatology,
C Mautalen, and
D Gonzalez, and
E L Blumenfeld, and
E Santini Araujo, and
F Schajowicz
January 1977,
Clinical orthopaedics and related research,
C Mautalen, and
D Gonzalez, and
E L Blumenfeld, and
E Santini Araujo, and
F Schajowicz
October 1980,
Arthritis and rheumatism,
C Mautalen, and
D Gonzalez, and
E L Blumenfeld, and
E Santini Araujo, and
F Schajowicz
May 1982,
Annals of internal medicine,
C Mautalen, and
D Gonzalez, and
E L Blumenfeld, and
E Santini Araujo, and
F Schajowicz
April 1973,
The Quarterly journal of medicine,
