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We conducted a two-center dose ranging study to evaluate the efficacy, tolerance, and toxicity of cefpimizole, a new cephalosporin, in the treatment of uncomplicated gonorrhea in 96 males. Twelve patients at each center were treated intramuscularly with single doses of 1.0, 0.5, 0.25, and 0.125 g of cefpimizole. All urethral infections were cured at the highest dose, but lower doses produced progressively decreasing cure rates of 90% (0.5 g), 83% (0.25 g), and 71% (0.125 g). Treatment failures of rectal and pharyngeal infections occurred at the highest dose level. Geometric mean MICs for cefpimizole for successfully and unsuccessfully treated volunteers were 0.088 and 0.282 micrograms/ml, respectively. A prominent adverse effect was clinically significant pain at the injection site, which occurred in 57 (59%) of 96 patients. Results of the study demonstrate that cefpimizole offers no advantage over currently available antibiotics in the treatment of uncomplicated gonorrhea in men.
E T Sandberg, and
P S Pegram, and
R E Roddy, and
H H Handsfield, and
K D Hampton, and
K M Shafran, and
E W Hook
December 1981,
Antimicrobial agents and chemotherapy,
E T Sandberg, and
P S Pegram, and
R E Roddy, and
H H Handsfield, and
K D Hampton, and
K M Shafran, and
E W Hook
July 1996,
Antimicrobial agents and chemotherapy,
E T Sandberg, and
P S Pegram, and
R E Roddy, and
H H Handsfield, and
K D Hampton, and
K M Shafran, and
E W Hook
July 1985,
Antimicrobial agents and chemotherapy,
E T Sandberg, and
P S Pegram, and
R E Roddy, and
H H Handsfield, and
K D Hampton, and
K M Shafran, and
E W Hook
January 1988,
Sexually transmitted diseases,
E T Sandberg, and
P S Pegram, and
R E Roddy, and
H H Handsfield, and
K D Hampton, and
K M Shafran, and
E W Hook
January 1983,
Sexually transmitted diseases,
E T Sandberg, and
P S Pegram, and
R E Roddy, and
H H Handsfield, and
K D Hampton, and
K M Shafran, and
E W Hook
August 2018,
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America,
E T Sandberg, and
P S Pegram, and
R E Roddy, and
H H Handsfield, and
K D Hampton, and
K M Shafran, and
E W Hook
January 1986,
Chemotherapy,
E T Sandberg, and
P S Pegram, and
R E Roddy, and
H H Handsfield, and
K D Hampton, and
K M Shafran, and
E W Hook
January 1984,
Sexually transmitted diseases,
E T Sandberg, and
P S Pegram, and
R E Roddy, and
H H Handsfield, and
K D Hampton, and
K M Shafran, and
E W Hook
October 1986,
Antimicrobial agents and chemotherapy,
E T Sandberg, and
P S Pegram, and
R E Roddy, and
H H Handsfield, and
K D Hampton, and
K M Shafran, and
E W Hook
October 1973,
The Journal of infectious diseases,
