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Rhamnolipid biosurfactants were continuously produced with Pseudomonas aeruginosa on the pilot plant scale. Production and downstream processing elaborated on the laboratory scale were adapted to the larger scale. Differences in performance resulting from the scale-up are discussed. A biosurfactant concentration of approximately 2.25 g liter-1 was achieved. The biosurfactant yield on glucose was 77 mg g-1 h-1, and the productivity was 147 mg liter-1 h-1, corresponding to a daily production of 80 g of biosurfactant. The first enrichment step consisted of an adsorption chromatography which was followed by an anion-exchange chromatography. The resulting product was 90% pure, and the overall recovery of active material was above 60% with the downstream processing used.
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A Fiechter
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January 2002,
Biotechnology progress,
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January 2005,
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August 2012,
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January 2009,
Microbiological research,
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July 1995,
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October 2015,
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January 2011,
Indian journal of microbiology,
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May 1999,
Bioscience, biotechnology, and biochemistry,
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January 2016,
PeerJ,
