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A total of 136 patients with uncomplicated gonorrhoea were treated with intramuscular cefoxitin 2 g (25 patients) or 1 g (111 patients) and oral probenecid 1 g. Cefoxitin 1 g cured 95% (42 out of 45 men and all of 14 women) with infections caused by penicillinase producing Neisseria gonorrhoeae (PPNG) strains and 98% (all of 38 men and 13 out of 14 women) with non-PPNG infections, giving an overall cure rate of 96%. The rate of postgonococcal urethritis (PGU) in men treated with 1 g cefoxitin was 28%. No serious side effects of treatment were observed in patients treated with either dose. The failure rate of 7% in men infected with PPNG strains who were treated with the 1 g dose is, however, disturbing. We therefore recommend that intramuscular cefoxitin 2 g and oral probenecid 1 g may be used to treat uncomplicated gonorrhoea, especially in areas where PPNG strains are common.
K B Lim, and
T Thirumoorthy, and
C T Lee, and
S N Tham, and
E H Sng, and
T Tan
January 1983,
Sexually transmitted diseases,
K B Lim, and
T Thirumoorthy, and
C T Lee, and
S N Tham, and
E H Sng, and
T Tan
May 1982,
Journal of the Medical Association of Thailand = Chotmaihet thangphaet,
K B Lim, and
T Thirumoorthy, and
C T Lee, and
S N Tham, and
E H Sng, and
T Tan
September 1979,
The New England journal of medicine,
K B Lim, and
T Thirumoorthy, and
C T Lee, and
S N Tham, and
E H Sng, and
T Tan
December 1996,
Antimicrobial agents and chemotherapy,
K B Lim, and
T Thirumoorthy, and
C T Lee, and
S N Tham, and
E H Sng, and
T Tan
August 1984,
The British journal of venereal diseases,
K B Lim, and
T Thirumoorthy, and
C T Lee, and
S N Tham, and
E H Sng, and
T Tan
December 1986,
Genitourinary medicine,
K B Lim, and
T Thirumoorthy, and
C T Lee, and
S N Tham, and
E H Sng, and
T Tan
December 1990,
Canada diseases weekly report = Rapport hebdomadaire des maladies au Canada,
K B Lim, and
T Thirumoorthy, and
C T Lee, and
S N Tham, and
E H Sng, and
T Tan
January 1982,
MMWR. Morbidity and mortality weekly report,
K B Lim, and
T Thirumoorthy, and
C T Lee, and
S N Tham, and
E H Sng, and
T Tan
May 1989,
Canada diseases weekly report = Rapport hebdomadaire des maladies au Canada,
K B Lim, and
T Thirumoorthy, and
C T Lee, and
S N Tham, and
E H Sng, and
T Tan
February 1983,
The British journal of venereal diseases,
