-transparent.png){kind=logo}
Metal-Free C-2-H Alkylation of Quinazolin-4-ones with Alkanes via Cross-Dehydrogenative Coupling. 2019
Shuai Mao, and
Kaixiu Luo, and
Lu Wang, and
Hong-Yi Zhao, and
Andrea Shergalis, and
Minhang Xin, and
Nouri Neamati, and
Yi Jin, and
San-Qi Zhang
Department of Medicinal Chemistry, School of Pharmacy , Xi'an Jiaotong University , Xi'an 710061 , China.
A practically useful approach for the cross-dehydrogenative coupling of quinazolin-4-one with simple nonactivated alkanes is reported. The products were smoothly formed under mild reaction conditions, within short reaction time at ambient temperature. The formation of new Csp3-Csp2 bonds occurred at the electron-poor C-2 position of quinazolin-4-one. The approach has the potential to be an important tool for the late-stage functionalization of advanced synthetic intermediates and may find many applications in medicinal chemistry.
| UI | MeSH Term | Description | Entries |
|---|
Related Publications
Shuai Mao, and
Kaixiu Luo, and
Lu Wang, and
Hong-Yi Zhao, and
Andrea Shergalis, and
Minhang Xin, and
Nouri Neamati, and
Yi Jin, and
San-Qi Zhang
December 2015,
Organic & biomolecular chemistry,
Shuai Mao, and
Kaixiu Luo, and
Lu Wang, and
Hong-Yi Zhao, and
Andrea Shergalis, and
Minhang Xin, and
Nouri Neamati, and
Yi Jin, and
San-Qi Zhang
January 2024,
Angewandte Chemie (International ed. in English),
Shuai Mao, and
Kaixiu Luo, and
Lu Wang, and
Hong-Yi Zhao, and
Andrea Shergalis, and
Minhang Xin, and
Nouri Neamati, and
Yi Jin, and
San-Qi Zhang
August 2019,
RSC advances,
Shuai Mao, and
Kaixiu Luo, and
Lu Wang, and
Hong-Yi Zhao, and
Andrea Shergalis, and
Minhang Xin, and
Nouri Neamati, and
Yi Jin, and
San-Qi Zhang
March 2017,
Angewandte Chemie (International ed. in English),
Shuai Mao, and
Kaixiu Luo, and
Lu Wang, and
Hong-Yi Zhao, and
Andrea Shergalis, and
Minhang Xin, and
Nouri Neamati, and
Yi Jin, and
San-Qi Zhang
May 2024,
Chemical communications (Cambridge, England),
Shuai Mao, and
Kaixiu Luo, and
Lu Wang, and
Hong-Yi Zhao, and
Andrea Shergalis, and
Minhang Xin, and
Nouri Neamati, and
Yi Jin, and
San-Qi Zhang
June 2021,
Organic & biomolecular chemistry,
Shuai Mao, and
Kaixiu Luo, and
Lu Wang, and
Hong-Yi Zhao, and
Andrea Shergalis, and
Minhang Xin, and
Nouri Neamati, and
Yi Jin, and
San-Qi Zhang
January 2006,
Journal of the American Chemical Society,
Shuai Mao, and
Kaixiu Luo, and
Lu Wang, and
Hong-Yi Zhao, and
Andrea Shergalis, and
Minhang Xin, and
Nouri Neamati, and
Yi Jin, and
San-Qi Zhang
July 2017,
Chemistry (Weinheim an der Bergstrasse, Germany),
Shuai Mao, and
Kaixiu Luo, and
Lu Wang, and
Hong-Yi Zhao, and
Andrea Shergalis, and
Minhang Xin, and
Nouri Neamati, and
Yi Jin, and
San-Qi Zhang
January 2016,
Beilstein journal of organic chemistry,
Shuai Mao, and
Kaixiu Luo, and
Lu Wang, and
Hong-Yi Zhao, and
Andrea Shergalis, and
Minhang Xin, and
Nouri Neamati, and
Yi Jin, and
San-Qi Zhang
January 2017,
The Journal of organic chemistry,
