Cox regression model with randomly censored covariates. 2019

Folefac D Atem, and Roland A Matsouaka, and Vincent E Zimmern
Department of Biostatistics and Data Science, University of Texas Health Science Center at Houston, Houston, TX, USA.

This paper deals with a Cox proportional hazards regression model, where some covariates of interest are randomly right-censored. While methods for censored outcomes have become ubiquitous in the literature, methods for censored covariates have thus far received little attention and, for the most part, dealt with the issue of limit-of-detection. For randomly censored covariates, an often-used method is the inefficient complete-case analysis (CCA) which consists in deleting censored observations in the data analysis. When censoring is not completely independent, the CCA leads to biased and spurious results. Methods for missing covariate data, including type I and type II covariate censoring as well as limit-of-detection do not readily apply due to the fundamentally different nature of randomly censored covariates. We develop a novel method for censored covariates using a conditional mean imputation based on either Kaplan-Meier estimates or a Cox proportional hazards model to estimate the effects of these covariates on a time-to-event outcome. We evaluate the performance of the proposed method through simulation studies and show that it provides good bias reduction and statistical efficiency. Finally, we illustrate the method using data from the Framingham Heart Study to assess the relationship between offspring and parental age of onset of cardiovascular events.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D012044 Regression Analysis Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable. Regression Diagnostics,Statistical Regression,Analysis, Regression,Analyses, Regression,Diagnostics, Regression,Regression Analyses,Regression, Statistical,Regressions, Statistical,Statistical Regressions
D002318 Cardiovascular Diseases Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM. Adverse Cardiac Event,Cardiac Events,Major Adverse Cardiac Events,Adverse Cardiac Events,Cardiac Event,Cardiac Event, Adverse,Cardiac Events, Adverse,Cardiovascular Disease,Disease, Cardiovascular,Event, Cardiac
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly

Related Publications

Folefac D Atem, and Roland A Matsouaka, and Vincent E Zimmern
September 2008, Statistics in medicine,
Folefac D Atem, and Roland A Matsouaka, and Vincent E Zimmern
December 2015, Biometrika,
Folefac D Atem, and Roland A Matsouaka, and Vincent E Zimmern
December 2020, Biometrics,
Folefac D Atem, and Roland A Matsouaka, and Vincent E Zimmern
December 2008, Lifetime data analysis,
Folefac D Atem, and Roland A Matsouaka, and Vincent E Zimmern
September 2008, Lifetime data analysis,
Folefac D Atem, and Roland A Matsouaka, and Vincent E Zimmern
March 2018, Biometrics,
Folefac D Atem, and Roland A Matsouaka, and Vincent E Zimmern
May 1989, Computer methods and programs in biomedicine,
Folefac D Atem, and Roland A Matsouaka, and Vincent E Zimmern
January 1999, Annual review of public health,
Folefac D Atem, and Roland A Matsouaka, and Vincent E Zimmern
October 2022, Statistics in medicine,
Folefac D Atem, and Roland A Matsouaka, and Vincent E Zimmern
September 2009, Biometrika,
Copied contents to your clipboard!