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The in vitro effects of bacteria-produced human interferons alpha 2, beta and gamma on several properties of peripheral blood leukocytes from different healthy donors were compared. Treatment with HuIFN-alpha 2 or HuIFN-beta resulted in inhibition of the proliferative response to phytohaemagglutinin and in closely parallel induction of 2'-5'-oligoadenylate synthetase activity. In contrast, HuIFN-gamma had no significant effect on these two activities. However, all three HuIFN were able to enhance natural killer cell cytotoxicity and the expression of HLA-DR surface antigens, with only quantitative variations from donor to donor. Similar results were observed with glycosylated recombinant hamster-cell-derived HuIFN-gamma and with natural HuIFN-gamma. These data demonstrate qualitative differences in the effects of HuIFN-gamma compared to those of HuIFN-alpha 2 or -beta on cells of the immune system.
C Billard, and
D Ferbus, and
J P Kolb, and
F Rosa, and
J Y Perrot, and
G Merlin, and
P Janiaud, and
N Raynaud, and
M N Thang, and
M Fellous
June 1994,
The Southeast Asian journal of tropical medicine and public health,
C Billard, and
D Ferbus, and
J P Kolb, and
F Rosa, and
J Y Perrot, and
G Merlin, and
P Janiaud, and
N Raynaud, and
M N Thang, and
M Fellous
April 1984,
Cellular immunology,
C Billard, and
D Ferbus, and
J P Kolb, and
F Rosa, and
J Y Perrot, and
G Merlin, and
P Janiaud, and
N Raynaud, and
M N Thang, and
M Fellous
December 1984,
Laboratory investigation; a journal of technical methods and pathology,
C Billard, and
D Ferbus, and
J P Kolb, and
F Rosa, and
J Y Perrot, and
G Merlin, and
P Janiaud, and
N Raynaud, and
M N Thang, and
M Fellous
January 1982,
Nihon rinsho. Japanese journal of clinical medicine,
C Billard, and
D Ferbus, and
J P Kolb, and
F Rosa, and
J Y Perrot, and
G Merlin, and
P Janiaud, and
N Raynaud, and
M N Thang, and
M Fellous
January 1985,
Voprosy virusologii,
C Billard, and
D Ferbus, and
J P Kolb, and
F Rosa, and
J Y Perrot, and
G Merlin, and
P Janiaud, and
N Raynaud, and
M N Thang, and
M Fellous
August 1988,
Journal of interferon research,
C Billard, and
D Ferbus, and
J P Kolb, and
F Rosa, and
J Y Perrot, and
G Merlin, and
P Janiaud, and
N Raynaud, and
M N Thang, and
M Fellous
October 1986,
Journal of interferon research,
C Billard, and
D Ferbus, and
J P Kolb, and
F Rosa, and
J Y Perrot, and
G Merlin, and
P Janiaud, and
N Raynaud, and
M N Thang, and
M Fellous
May 1988,
Journal of the National Cancer Institute,
C Billard, and
D Ferbus, and
J P Kolb, and
F Rosa, and
J Y Perrot, and
G Merlin, and
P Janiaud, and
N Raynaud, and
M N Thang, and
M Fellous
January 1987,
Journal of biological regulators and homeostatic agents,
C Billard, and
D Ferbus, and
J P Kolb, and
F Rosa, and
J Y Perrot, and
G Merlin, and
P Janiaud, and
N Raynaud, and
M N Thang, and
M Fellous
October 1986,
Journal of interferon research,
