Biomaterial Database

Feasibility of poly-vinyl alcohol/starch/glycerol/citric acid composite films for wound dressing applications. 2019

Aritra Das, and Ramagopal Uppaluri, and Chandan Das

Department of Chemical Engineering, Indian Institute of Technology Guwahati, Assam 781039, India.

This work addresses the competence of PVA/starch/citric acid (PVA/St/CA) based composite films for wound dressing applications. Literature reported composition of PVA, starch and glycerol were adopted and the optimality of crosslinking temperature (40 to 60 °C) and citric acid concentration (0.5 to 3 g) have been investigated during solution casting based composite film fabrication. The prepared polymer films have been characterized with swelling index, solubility based biodegradability, gel fraction, mechanical strength, water vapor transmission rate and antimicrobial effectiveness. The optimized film (composition) were analyzed to possess excellent swelling (260.5 ± 2.9%) and in-vitro degradation (45.5 ± 1.8-59.8 ± 0.4% degradation, during 14 days) characteristics. Further, the film possesses enhanced combinations of water vapor transmission rate and antibacterial activity with Gram-negative (Escherichia coli) and Gram-positive (Listeria monocytogenes) bacteria. With all these promising characteristics, the low temperature (50 °C) and long duration (12 h) fabricated PVA-St-CA films have been inferred to be a potential candidate for wound dressing applications.

UI	MeSH Term	Description	Entries
D008422	Materials Testing	The testing of materials and devices, especially those used for PROSTHESES AND IMPLANTS; SUTURES; TISSUE ADHESIVES; etc., for hardness, strength, durability, safety, efficacy, and biocompatibility.	Biocompatibility Testing,Biocompatible Materials Testing,Hemocompatibility Testing,Testing, Biocompatible Materials,Testing, Hemocompatible Materials,Hemocompatibility Testings,Hemocompatible Materials Testing,Materials Testing, Biocompatible,Materials Testing, Hemocompatible,Testing, Biocompatibility,Testing, Hemocompatibility,Testing, Materials,Testings, Biocompatibility
D010539	Permeability	Property of membranes and other structures to permit passage of light, heat, gases, liquids, metabolites, and mineral ions.	Permeabilities
D011142	Polyvinyl Alcohol	A polymer prepared from polyvinyl acetates by replacement of the acetate groups with hydroxyl groups. It is used as a pharmaceutic aid and ophthalmic lubricant as well as in the manufacture of surface coatings artificial sponges, cosmetics, and other products.	Liquifilm Tears,Polyviol,Alcohol, Polyvinyl,Tears, Liquifilm
D005990	Glycerol	A trihydroxy sugar alcohol that is an intermediate in carbohydrate and lipid metabolism. It is used as a solvent, emollient, pharmaceutical agent, or sweetening agent.	1,2,3-Propanetriol,Glycerin,1,2,3-Trihydroxypropane,Glycerine
D000900	Anti-Bacterial Agents	Substances that inhibit the growth or reproduction of BACTERIA.	Anti-Bacterial Agent,Anti-Bacterial Compound,Anti-Mycobacterial Agent,Antibacterial Agent,Antibiotics,Antimycobacterial Agent,Bacteriocidal Agent,Bacteriocide,Anti-Bacterial Compounds,Anti-Mycobacterial Agents,Antibacterial Agents,Antibiotic,Antimycobacterial Agents,Bacteriocidal Agents,Bacteriocides,Agent, Anti-Bacterial,Agent, Anti-Mycobacterial,Agent, Antibacterial,Agent, Antimycobacterial,Agent, Bacteriocidal,Agents, Anti-Bacterial,Agents, Anti-Mycobacterial,Agents, Antibacterial,Agents, Antimycobacterial,Agents, Bacteriocidal,Anti Bacterial Agent,Anti Bacterial Agents,Anti Bacterial Compound,Anti Bacterial Compounds,Anti Mycobacterial Agent,Anti Mycobacterial Agents,Compound, Anti-Bacterial,Compounds, Anti-Bacterial
D001672	Biocompatible Materials	Synthetic or natural materials, other than DRUGS, that are used to replace or repair any body TISSUES or bodily function.	Biomaterials,Bioartificial Materials,Hemocompatible Materials,Bioartificial Material,Biocompatible Material,Biomaterial,Hemocompatible Material,Material, Bioartificial,Material, Biocompatible,Material, Hemocompatible
D001684	Biological Dressings	Human or animal tissue used as temporary wound coverings.	Allograft Dressings,Amniotic Membrane Dressings,Dressings, Biological,Heterograft Dressings,Homograft Dressings,Pig Skin Dressings,Porcine Xenograft Dressings,Xenograft Dressings,Biologic Dressing,Dressing, Biological,Allograft Dressing,Amniotic Membrane Dressing,Biologic Dressings,Biological Dressing,Dressing, Allograft,Dressing, Amniotic Membrane,Dressing, Biologic,Dressing, Heterograft,Dressing, Homograft,Dressing, Pig Skin,Dressing, Porcine Xenograft,Dressing, Xenograft,Dressings, Allograft,Dressings, Amniotic Membrane,Dressings, Biologic,Dressings, Heterograft,Dressings, Homograft,Dressings, Pig Skin,Dressings, Porcine Xenograft,Dressings, Xenograft,Heterograft Dressing,Homograft Dressing,Pig Skin Dressing,Porcine Xenograft Dressing,Xenograft Dressing,Xenograft Dressing, Porcine,Xenograft Dressings, Porcine
D013213	Starch	Any of a group of polysaccharides of the general formula (C6-H10-O5)n, composed of a long-chain polymer of glucose in the form of amylose and amylopectin. It is the chief storage form of energy reserve (carbohydrates) in plants.	Amylomaize Starch,Amylum,Cornstarch,Keoflo,Starch, Amylomaize
D013227	Steam	Water in its gaseous state. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)	Water Vapor,Steams,Vapor, Water,Vapors, Water,Water Vapors
D013696	Temperature	The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.	Temperatures