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An epidemiological study was conducted to estimate the proportion of infants on total parenteral nutrition (TPN) who developed cholestasis and to identify risk factors associated with the development of this disease. Data were abstracted from medical records of 624 infants less than or equal to 30 days of age who were treated with TPN. A case of TPN-related cholestasis was defined as an infant whose serum level of direct bilirubin was greater than or equal to 1.5 mg/dl subsequent to initiation of TPN. Risk factors were assessed using multiple logistic regression analysis. Forty-six of 624 infants in the cohort (7.4%) were classified as having TPN-related cholestasis. The multivariable analysis indicated that cholestasis was associated with intracranial hemorrhage, patent ductus arteriosus, sepsis and gastrointestinal conditions that require surgery. Two distinct processes appear to have occurred: in infants who experienced patent ductus arteriosus or intracranial hemorrhage (conditions associated with hypoxia) where TPN may be the necessary trigger for the development of cholestasis, and in infants with gastrointestinal conditions requiring surgery or sepsis, where cholestasis may develop with or without parenteral infusions.
R L Bell, and
G D Ferry, and
E O Smith, and
R J Shulman, and
B L Christensen, and
D R Labarthe, and
C A Wills
January 1985,
Hepatology (Baltimore, Md.),
R L Bell, and
G D Ferry, and
E O Smith, and
R J Shulman, and
B L Christensen, and
D R Labarthe, and
C A Wills
August 1999,
Clinics in liver disease,
R L Bell, and
G D Ferry, and
E O Smith, and
R J Shulman, and
B L Christensen, and
D R Labarthe, and
C A Wills
February 1986,
Revista espanola de las enfermedades del aparato digestivo,
R L Bell, and
G D Ferry, and
E O Smith, and
R J Shulman, and
B L Christensen, and
D R Labarthe, and
C A Wills
January 1986,
Journal of pediatric gastroenterology and nutrition,
R L Bell, and
G D Ferry, and
E O Smith, and
R J Shulman, and
B L Christensen, and
D R Labarthe, and
C A Wills
January 2014,
Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association,
R L Bell, and
G D Ferry, and
E O Smith, and
R J Shulman, and
B L Christensen, and
D R Labarthe, and
C A Wills
July 2000,
Journal of pediatric surgery,
R L Bell, and
G D Ferry, and
E O Smith, and
R J Shulman, and
B L Christensen, and
D R Labarthe, and
C A Wills
January 1986,
Journal of pediatric gastroenterology and nutrition,
R L Bell, and
G D Ferry, and
E O Smith, and
R J Shulman, and
B L Christensen, and
D R Labarthe, and
C A Wills
April 1983,
Lancet (London, England),
R L Bell, and
G D Ferry, and
E O Smith, and
R J Shulman, and
B L Christensen, and
D R Labarthe, and
C A Wills
April 1983,
Lancet (London, England),
R L Bell, and
G D Ferry, and
E O Smith, and
R J Shulman, and
B L Christensen, and
D R Labarthe, and
C A Wills
May 1983,
Lancet (London, England),
