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The value of predictive tests in bromocriptine therapy and the effects of long-term bromocriptine therapy were investigated in acromegalic patients. In 72 acromegalic patients, there was a tendency for patients with a plasma GH response to TRH or with an elevated basal plasma PRL level, but without a plasma GH response to LHRH, to have a plasma GH response to bromocriptine, though statistical analysis did not reveal a significant difference. Acute and chronic effects of bromocriptine were significantly interrelated, while the chronic effect of bromocriptine and abnormal plasma GH response to TRH or elevated plasma PRL levels were not, in 18 acromegalic patients. These results suggest that the acute bromocriptine test is a better predictor than the TRH test and plasma PRL levels for evaluating the effects of chronic bromocriptine therapy. To maintain the low plasma GH levels, increasing doses of bromocriptine were needed in most patients, and failure to control the elevated GH level despite increasing doses was observed in 2 of 18 patients.
T Karashima, and
K Kato, and
H Nawata, and
S Ikuyama, and
H Ibayashi, and
K Okamura, and
A Shiroozu, and
T Nakashima, and
M Fujishima
October 1980,
Endokrinologie,
T Karashima, and
K Kato, and
H Nawata, and
S Ikuyama, and
H Ibayashi, and
K Okamura, and
A Shiroozu, and
T Nakashima, and
M Fujishima
April 1981,
Postgraduate medical journal,
T Karashima, and
K Kato, and
H Nawata, and
S Ikuyama, and
H Ibayashi, and
K Okamura, and
A Shiroozu, and
T Nakashima, and
M Fujishima
April 1977,
British medical journal,
T Karashima, and
K Kato, and
H Nawata, and
S Ikuyama, and
H Ibayashi, and
K Okamura, and
A Shiroozu, and
T Nakashima, and
M Fujishima
April 1978,
Acta endocrinologica,
T Karashima, and
K Kato, and
H Nawata, and
S Ikuyama, and
H Ibayashi, and
K Okamura, and
A Shiroozu, and
T Nakashima, and
M Fujishima
January 1978,
Acta endocrinologica. Supplementum,
T Karashima, and
K Kato, and
H Nawata, and
S Ikuyama, and
H Ibayashi, and
K Okamura, and
A Shiroozu, and
T Nakashima, and
M Fujishima
November 1978,
Acta endocrinologica,
T Karashima, and
K Kato, and
H Nawata, and
S Ikuyama, and
H Ibayashi, and
K Okamura, and
A Shiroozu, and
T Nakashima, and
M Fujishima
December 1975,
Lancet (London, England),
T Karashima, and
K Kato, and
H Nawata, and
S Ikuyama, and
H Ibayashi, and
K Okamura, and
A Shiroozu, and
T Nakashima, and
M Fujishima
June 1984,
Acta endocrinologica,
T Karashima, and
K Kato, and
H Nawata, and
S Ikuyama, and
H Ibayashi, and
K Okamura, and
A Shiroozu, and
T Nakashima, and
M Fujishima
September 1977,
Vnitrni lekarstvi,
T Karashima, and
K Kato, and
H Nawata, and
S Ikuyama, and
H Ibayashi, and
K Okamura, and
A Shiroozu, and
T Nakashima, and
M Fujishima
February 1982,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
