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Slow intravenous infusion of pentylenetetrazol was used to measure the convulsive threshold in mice. The anticonvulsant effects of clobazam, clonazepam, diazepam, lorazepam, sodium phenobarbitone and sodium valproate were assessed in naive animals and compared with the effects of the same compounds in animals which had been pretreated (twice daily for 3 days) with one of the benzodiazepines or sodium valproate. Cross-tolerance was observed between all the benzodiazepines but not between benzodiazepines and sodium phenobarbitone. Animals pretreated with the benzodiazepines were cross-tolerant to valproate, but the converse was not true; nor did sodium valproate induce tolerance to itself.
J P Gent, and
M Bentley, and
M Feely, and
J R Haigh
July 1988,
European journal of pharmacology,
J P Gent, and
M Bentley, and
M Feely, and
J R Haigh
July 1990,
The American journal of psychiatry,
J P Gent, and
M Bentley, and
M Feely, and
J R Haigh
October 1994,
Praxis,
J P Gent, and
M Bentley, and
M Feely, and
J R Haigh
May 1982,
Life sciences,
J P Gent, and
M Bentley, and
M Feely, and
J R Haigh
September 1986,
Arzneimittel-Forschung,
J P Gent, and
M Bentley, and
M Feely, and
J R Haigh
January 1992,
Pharmacology, biochemistry, and behavior,
J P Gent, and
M Bentley, and
M Feely, and
J R Haigh
June 1985,
Toxicology letters,
J P Gent, and
M Bentley, and
M Feely, and
J R Haigh
January 1989,
Immunopharmacology and immunotoxicology,
J P Gent, and
M Bentley, and
M Feely, and
J R Haigh
February 1998,
Annals of neurology,
J P Gent, and
M Bentley, and
M Feely, and
J R Haigh
January 1981,
Neurology,
