BIOMAT Database Logo BIOMAT Database Logo

Human cells are permissive for the productive infection of porcine circovirus type 2 in vitro. 2019

Xiaohui Liu, and Ting Ouyang, and Hongsheng Ouyang, and Xiaohua Liu, and Guyu Niu, and Wang Huo, and Weihong Yin, and Daxin Pang, and Linzhu Ren
Jilin Provincial Key Laboratory of Animal Embryo Engineering, College of Animal Sciences, Jilin University, 5333 Xi'an Road, Changchun, 130062, China.

Porcine circovirus 2 (PCV2) is the main pathogen of porcine circovirus diseases and porcine circovirus-associated diseases, which are widespread in swine-producing countries. However, there is controversy regarding the susceptibility of human cells to PCV2 infection. In this study, human cell lines were infected with PCV2 and blind passaged several times. PCV2 entered and replicated in human cells, and infectious virions were generated, indicating that human cell lines were permissive to PCV2 replication. Furthermore, PCV2 replication in human cell lines was enhanced by D-glucosamine or concanavalin A (ConA). However, the infection efficiency of PCV2 was lower in human cells than in PK-15 cells, suggesting that PCV2 infection was limited in human cells. Our study reveals that human cells are permissive for the productive infection of porcine circovirus type 2 in vitro.

UI MeSH Term Description Entries
D002460 Cell Line Established cell cultures that have the potential to propagate indefinitely. Cell Lines,Line, Cell,Lines, Cell
D003208 Concanavalin A A MANNOSE/GLUCOSE binding lectin isolated from the jack bean (Canavalia ensiformis). It is a potent mitogen used to stimulate cell proliferation in lymphocytes, primarily T-lymphocyte, cultures.
D005944 Glucosamine 2-Amino-2-Deoxyglucose,Dona,Dona S,Glucosamine Sulfate,Hespercorbin,Xicil,2 Amino 2 Deoxyglucose,Sulfate, Glucosamine
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013552 Swine Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA). Phacochoerus,Pigs,Suidae,Warthogs,Wart Hogs,Hog, Wart,Hogs, Wart,Wart Hog
D013553 Swine Diseases Diseases of domestic swine and of the wild boar of the genus Sus. Disease, Swine,Diseases, Swine,Swine Disease
D014779 Virus Replication The process of intracellular viral multiplication, consisting of the synthesis of PROTEINS; NUCLEIC ACIDS; and sometimes LIPIDS, and their assembly into a new infectious particle. Viral Replication,Replication, Viral,Replication, Virus,Replications, Viral,Replications, Virus,Viral Replications,Virus Replications
D017925 Circovirus A genus of the family CIRCOVIRIDAE that infects SWINE; PSITTACINES; and non-psittacine BIRDS. Species include Beak and feather disease virus causing a fatal disease in psittacine birds, and Porcine circovirus causing postweaning multisystemic wasting syndrome in pigs (PORCINE POSTWEANING MULTISYSTEMIC WASTING SYNDROME). Beak and feather disease virus,Circovirus, Porcine,Porcine Circovirus,Circoviruses, Porcine,Porcine Circoviruses
D018173 Circoviridae Infections Virus diseases caused by the CIRCOVIRIDAE. Circovirus Infections,Infections, Circoviridae,Infections, Circovirus,Circoviridae Infection,Circovirus Infection,Infection, Circoviridae,Infection, Circovirus

Related Publications

Xiaohui Liu, and Ting Ouyang, and Hongsheng Ouyang, and Xiaohua Liu, and Guyu Niu, and Wang Huo, and Weihong Yin, and Daxin Pang, and Linzhu Ren
Productive infection of human hepatocellular carcinoma cells by porcine circovirus type 1.
October 2011, Vaccine,
Xiaohui Liu, and Ting Ouyang, and Hongsheng Ouyang, and Xiaohua Liu, and Guyu Niu, and Wang Huo, and Weihong Yin, and Daxin Pang, and Linzhu Ren
Highly permissive subclone of the porcine kidney cell line for porcine circovirus type 2 production.
February 2013, Journal of virological methods,
Xiaohui Liu, and Ting Ouyang, and Hongsheng Ouyang, and Xiaohua Liu, and Guyu Niu, and Wang Huo, and Weihong Yin, and Daxin Pang, and Linzhu Ren
Infection studies on human cell lines with porcine circovirus type 1 and porcine circovirus type 2.
May 2004, Xenotransplantation,
Xiaohui Liu, and Ting Ouyang, and Hongsheng Ouyang, and Xiaohua Liu, and Guyu Niu, and Wang Huo, and Weihong Yin, and Daxin Pang, and Linzhu Ren
Human fibroblasts are permissive for porcine cytomegalovirus in vitro.
July 2008, Transplantation,
Xiaohui Liu, and Ting Ouyang, and Hongsheng Ouyang, and Xiaohua Liu, and Guyu Niu, and Wang Huo, and Weihong Yin, and Daxin Pang, and Linzhu Ren
In vitro studies on the infection and replication of porcine circovirus type 2 in cells of the porcine immune system.
August 2003, Veterinary immunology and immunopathology,
Xiaohui Liu, and Ting Ouyang, and Hongsheng Ouyang, and Xiaohua Liu, and Guyu Niu, and Wang Huo, and Weihong Yin, and Daxin Pang, and Linzhu Ren
Human trophoblast cells express CD4 and are permissive for productive infection with HIV-1.
April 1992, Clinical and experimental immunology,
Xiaohui Liu, and Ting Ouyang, and Hongsheng Ouyang, and Xiaohua Liu, and Guyu Niu, and Wang Huo, and Weihong Yin, and Daxin Pang, and Linzhu Ren
Effect of porcine circovirus type 2 infection and replication on activated porcine peripheral blood mononuclear cells in vitro.
February 2009, Veterinary immunology and immunopathology,
Xiaohui Liu, and Ting Ouyang, and Hongsheng Ouyang, and Xiaohua Liu, and Guyu Niu, and Wang Huo, and Weihong Yin, and Daxin Pang, and Linzhu Ren
Cellular pathogenesis of porcine circovirus type 2 infection.
June 2013, Virus research,
Xiaohui Liu, and Ting Ouyang, and Hongsheng Ouyang, and Xiaohua Liu, and Guyu Niu, and Wang Huo, and Weihong Yin, and Daxin Pang, and Linzhu Ren
Immunologic features of porcine circovirus type 2 infection.
January 2002, Viral immunology,
Xiaohui Liu, and Ting Ouyang, and Hongsheng Ouyang, and Xiaohua Liu, and Guyu Niu, and Wang Huo, and Weihong Yin, and Daxin Pang, and Linzhu Ren
Human Endometrial Stromal Cells Are Highly Permissive To Productive Infection by Zika Virus.
March 2017, Scientific reports,
Copied contents to your clipboard!