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Aphidicolin, an inhibitor of DNA polymerase alpha, blocks DNA synthesis and cell division in sea urchin embryos. The effects of this inhibition appear to be stage dependent. Blastulae treated with aphidicolin before the thickening of the vegetal plate undergo developmental arrest prior to gastrulation. The extent of inhibition of DNA synthesis varies from 60 to 93% in these embryos. However, when aphidicolin is added after the vegetal plate has thickened, development continues normally through pluteus formation, even though DNA synthesis is inhibited by greater than or equal to 90% and cell division has ceased. These observations indicate that, from the vegetal plate stage onward, morphogenesis and overt differentiation are independent of DNA synthesis and cell division.
L Stephens, and
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F Wilt
June 1990,
Development, growth & differentiation,
L Stephens, and
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F Wilt
August 1987,
Development (Cambridge, England),
L Stephens, and
J Hardin, and
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August 1995,
Cell biology international,
L Stephens, and
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F Wilt
September 1981,
Experimental cell research,
L Stephens, and
J Hardin, and
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F Wilt
May 2018,
Developmental biology,
L Stephens, and
J Hardin, and
R Keller, and
F Wilt
January 2016,
Current topics in developmental biology,
L Stephens, and
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F Wilt
January 2000,
Zygote (Cambridge, England),
L Stephens, and
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F Wilt
April 1957,
Experimental cell research,
L Stephens, and
J Hardin, and
R Keller, and
F Wilt
January 2004,
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology,
L Stephens, and
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R Keller, and
F Wilt
January 1984,
Experimental cell biology,
