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Eight female patients with drug-induced agranulocytosis (five patients with definite seropositive rheumatoid arthritis (RA), three patients with upper respiratory infections) were studied for the presence of HLA-B27 and antinuclear antibodies (ANA). Five of eight patients were found to be HLA-B27 positive and all RA patients had ANA in their serum. The frequency of HLA-B27 and ANA was found to be significantly different from control groups. It is concluded that the occurrence of HLA-B27 and ANA was found to be significantly different from control groups. It is concluded that the occurrence of HLA-B27 in female patients with seropositive RA (especially in those with ANA) and of HLA-B27 alone in other individuals could reflect an increased risk for drug-induced agranulocytosis.
K L Schmidt, and
C Mueller-Eckhardt, and
H Breithaupt
October 1977,
Lancet (London, England),
K L Schmidt, and
C Mueller-Eckhardt, and
H Breithaupt
January 1981,
International archives of allergy and applied immunology,
K L Schmidt, and
C Mueller-Eckhardt, and
H Breithaupt
August 1990,
Immunology today,
K L Schmidt, and
C Mueller-Eckhardt, and
H Breithaupt
January 1976,
Drugs,
K L Schmidt, and
C Mueller-Eckhardt, and
H Breithaupt
February 2018,
Zeitschrift fur Rheumatologie,
K L Schmidt, and
C Mueller-Eckhardt, and
H Breithaupt
November 1983,
British journal of rheumatology,
K L Schmidt, and
C Mueller-Eckhardt, and
H Breithaupt
September 1997,
The British journal of ophthalmology,
K L Schmidt, and
C Mueller-Eckhardt, and
H Breithaupt
November 2002,
Scandinavian journal of gastroenterology,
K L Schmidt, and
C Mueller-Eckhardt, and
H Breithaupt
January 1982,
Life sciences,
K L Schmidt, and
C Mueller-Eckhardt, and
H Breithaupt
November 1993,
Arthritis and rheumatism,
