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We conducted a randomized clinical trial comparing a single intramuscular dose of 125 mg of ceftriaxone with a single intramuscular dose of 75 mg of kanamycin followed by topical gentamicin for seven days, and with a single intramuscular dose of 75 mg of kanamycin followed by topical tetracycline for seven days, in the treatment of gonococcal ophthalmia neonatorum in Nairobi, Kenya. Of 122 newborns with culture-proved gonococcal ophthalmia neonatorum, 105 returned for follow-up. Sixty-one infants (54 percent) received ceftriaxone, 32 received kanamycin plus topical gentamicin, and 29 received kanamycin plus topical tetracycline. Sixty-six (54 percent) of the Neisseria gonorrhoeae isolates were penicillinase producing. All 55 newborns who received ceftriaxone and returned for follow-up were clinically and microbiologically cured. One of 26 returning newborns who received kanamycin plus tetracycline and 2 of 24 returning newborns who received kanamycin plus gentamicin had persistent or recurrent gonococcal conjunctivitis. Ceftriaxone also eradicated oropharyngeal gonococcal infection in 18 newborns, whereas oropharyngeal infection persisted in 2 of 8 newborns who had received kanamycin (P not significant). We conclude that 125 mg of ceftriaxone as a single intramuscular dose is very effective therapy for gonococcal ophthalmia neonatorum, with marked efficacy against extraocular infection and without the need for concomitant topical antimicrobial therapy.
M Laga, and
W Naamara, and
R C Brunham, and
L J D'Costa, and
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P Piot, and
D Kunimoto, and
J O Ndinya-Achola, and
L Slaney, and
A R Ronald
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M Laga, and
W Naamara, and
R C Brunham, and
L J D'Costa, and
H Nsanze, and
P Piot, and
D Kunimoto, and
J O Ndinya-Achola, and
L Slaney, and
A R Ronald
December 1984,
Lancet (London, England),
M Laga, and
W Naamara, and
R C Brunham, and
L J D'Costa, and
H Nsanze, and
P Piot, and
D Kunimoto, and
J O Ndinya-Achola, and
L Slaney, and
A R Ronald
July 1988,
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M Laga, and
W Naamara, and
R C Brunham, and
L J D'Costa, and
H Nsanze, and
P Piot, and
D Kunimoto, and
J O Ndinya-Achola, and
L Slaney, and
A R Ronald
June 1987,
The New England journal of medicine,
M Laga, and
W Naamara, and
R C Brunham, and
L J D'Costa, and
H Nsanze, and
P Piot, and
D Kunimoto, and
J O Ndinya-Achola, and
L Slaney, and
A R Ronald
January 1987,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
M Laga, and
W Naamara, and
R C Brunham, and
L J D'Costa, and
H Nsanze, and
P Piot, and
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J O Ndinya-Achola, and
L Slaney, and
A R Ronald
January 1988,
Sexually transmitted diseases,
M Laga, and
W Naamara, and
R C Brunham, and
L J D'Costa, and
H Nsanze, and
P Piot, and
D Kunimoto, and
J O Ndinya-Achola, and
L Slaney, and
A R Ronald
December 2000,
Indian pediatrics,
M Laga, and
W Naamara, and
R C Brunham, and
L J D'Costa, and
H Nsanze, and
P Piot, and
D Kunimoto, and
J O Ndinya-Achola, and
L Slaney, and
A R Ronald
November 1986,
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M Laga, and
W Naamara, and
R C Brunham, and
L J D'Costa, and
H Nsanze, and
P Piot, and
D Kunimoto, and
J O Ndinya-Achola, and
L Slaney, and
A R Ronald
January 1949,
Eye, ear, nose & throat monthly,
M Laga, and
W Naamara, and
R C Brunham, and
L J D'Costa, and
H Nsanze, and
P Piot, and
D Kunimoto, and
J O Ndinya-Achola, and
L Slaney, and
A R Ronald
April 2021,
Journal francais d'ophtalmologie,
