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Formation of syncytia, with progression to cell death, is a characteristic feature of in vitro cultures of susceptible cells infected with human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV). Viral antigen-positive multinucleated giant cells have also been observed in histological sections from infected individuals. In vitro, formation of these multinucleated giant cells occurs through cell fusion which is dependent on cell-surface expression of the differentiation antigen CD4. Utilizing a recombinant vaccinia virus containing the gene for the envelope glycoprotein of HTLV-III/LAV, we demonstrate that cell-surface expression of this protein, in the absence of other HTLV-III/LAV structural or regulatory proteins, is sufficient to induce CD4-dependent cell fusion, leading to cell death, one of the characteristic manifestations of AIDS (acquired immune deficiency syndrome) virus cytopathology. This process may contribute to the loss of CD4+ T cells seen in AIDS.
J D Lifson, and
M B Feinberg, and
G R Reyes, and
L Rabin, and
B Banapour, and
S Chakrabarti, and
B Moss, and
F Wong-Staal, and
K S Steimer, and
E G Engleman
January 1986,
Nature,
J D Lifson, and
M B Feinberg, and
G R Reyes, and
L Rabin, and
B Banapour, and
S Chakrabarti, and
B Moss, and
F Wong-Staal, and
K S Steimer, and
E G Engleman
January 1987,
Haematology and blood transfusion,
J D Lifson, and
M B Feinberg, and
G R Reyes, and
L Rabin, and
B Banapour, and
S Chakrabarti, and
B Moss, and
F Wong-Staal, and
K S Steimer, and
E G Engleman
January 1986,
Nature,
J D Lifson, and
M B Feinberg, and
G R Reyes, and
L Rabin, and
B Banapour, and
S Chakrabarti, and
B Moss, and
F Wong-Staal, and
K S Steimer, and
E G Engleman
September 1985,
Science (New York, N.Y.),
J D Lifson, and
M B Feinberg, and
G R Reyes, and
L Rabin, and
B Banapour, and
S Chakrabarti, and
B Moss, and
F Wong-Staal, and
K S Steimer, and
E G Engleman
February 1987,
Journal of immunology (Baltimore, Md. : 1950),
J D Lifson, and
M B Feinberg, and
G R Reyes, and
L Rabin, and
B Banapour, and
S Chakrabarti, and
B Moss, and
F Wong-Staal, and
K S Steimer, and
E G Engleman
January 1986,
Nordisk medicin,
J D Lifson, and
M B Feinberg, and
G R Reyes, and
L Rabin, and
B Banapour, and
S Chakrabarti, and
B Moss, and
F Wong-Staal, and
K S Steimer, and
E G Engleman
March 1986,
Deutsche medizinische Wochenschrift (1946),
J D Lifson, and
M B Feinberg, and
G R Reyes, and
L Rabin, and
B Banapour, and
S Chakrabarti, and
B Moss, and
F Wong-Staal, and
K S Steimer, and
E G Engleman
May 1986,
Deutsche medizinische Wochenschrift (1946),
J D Lifson, and
M B Feinberg, and
G R Reyes, and
L Rabin, and
B Banapour, and
S Chakrabarti, and
B Moss, and
F Wong-Staal, and
K S Steimer, and
E G Engleman
November 1985,
Biochemical pharmacology,
J D Lifson, and
M B Feinberg, and
G R Reyes, and
L Rabin, and
B Banapour, and
S Chakrabarti, and
B Moss, and
F Wong-Staal, and
K S Steimer, and
E G Engleman
November 1985,
Lancet (London, England),
