Biomaterial Database

The history of treatment of cleft lip and palate. 1986

M Perko

The history of surgery of cleft lip and palates reaches as far backwards as the prechristian era to 390 B.C. when for the first time a cleft lip was closed successfully in China. Although Egyptian and Greek medicines developed to a remarkable degree, no descriptions of cleft operations have survived. In the middle ages operations on cleft lip have been several times described. A successful operation on a cleft palate did however not occur until 1816. This can be explained by the fact that cleft palates were thought to be secondary to syphilis, but also because without anaesthetic this operation was extremely painful and difficult. Graefe in 1816 [20a] and Roux in 1819 [49] published the first satisfactory results. After the introduction of chloroform cleft surgery made remarkable progress. The development of cleft surgery has been chronologically described and finally the present state of affairs is discussed.

UI	MeSH Term	Description	Entries
D002648	Child	A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL.	Children
D002971	Cleft Lip	Congenital defect in the upper lip where the maxillary prominence fails to merge with the merged medial nasal prominences. It is thought to be caused by faulty migration of the mesoderm in the head region.	Harelip,Cleft Lips,Harelips,Lip, Cleft,Lips, Cleft
D002972	Cleft Palate	Congenital fissure of the soft and/or hard palate, due to faulty fusion.	Cleft Palate, Isolated,Cleft Palates,Palate, Cleft,Palates, Cleft
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D049669	History, 16th Century	Time period from 1501 through 1600 of the common era.	16th Century History,16th Cent. History (Medicine),16th Cent. History of Medicine,16th Cent. Medicine,Historical Events, 16th Century,History of Medicine, 16th Cent.,History, Sixteenth Century,Medical History, 16th Cent.,Medicine, 16th Cent.,16th Cent. Histories (Medicine),16th Century Histories,Cent. Histories, 16th (Medicine),Cent. History, 16th (Medicine),Century Histories, 16th,Century Histories, Sixteenth,Century History, 16th,Century History, Sixteenth,Histories, 16th Cent. (Medicine),Histories, 16th Century,Histories, Sixteenth Century,History, 16th Cent. (Medicine),Sixteenth Century Histories,Sixteenth Century History
D049670	History, 17th Century	Time period from 1601 through 1700 of the common era.	17th Century History,17th Cent. History (Medicine),17th Cent. History of Medicine,17th Cent. Medicine,Historical Events, 17th Century,History of Medicine, 17th Cent.,History, Seventeenth Century,Medical History, 17th Cent.,Medicine, 17th Cent.,17th Cent. Histories (Medicine),17th Century Histories,Cent. Histories, 17th (Medicine),Century Histories, Seventeenth,Century History, 17th,Century History, Seventeenth,Histories, 17th Cent. (Medicine),Histories, 17th Century,Histories, Seventeenth Century,History, 17th Cent. (Medicine),Seventeenth Century Histories,Seventeenth Century History
D049671	History, 18th Century	Time period from 1701 through 1800 of the common era.	18th Century History,18th Cent. History (Medicine),18th Cent. History of Medicine,18th Cent. Medicine,Historical Events, 18th Century,History of Medicine, 18th Cent.,History, Eighteenth Century,Medical History, 18th Cent.,Medicine, 18th Cent.,18th Century Histories,Cent. History, 18th (Medicine),Cent. Medicine, 18th,Century Histories, 18th,Century Histories, Eighteenth,Century History, 18th,Century History, Eighteenth,Eighteenth Century Histories,Eighteenth Century History,Histories, 18th Century,Histories, Eighteenth Century,History, 18th Cent. (Medicine)
D049672	History, 19th Century	Time period from 1801 through 1900 of the common era.	19th Century History,19th Cent. History (Medicine),19th Cent. History of Medicine,19th Cent. Medicine,Historical Events, 19th Century,History of Medicine, 19th Cent.,History, Nineteenth Century,Medical History, 19th Cent.,Medicine, 19th Cent.,19th Cent. Histories (Medicine),19th Century Histories,Cent. Histories, 19th (Medicine),Cent. History, 19th (Medicine),Century Histories, 19th,Century Histories, Nineteenth,Century History, 19th,Century History, Nineteenth,Histories, 19th Cent. (Medicine),Histories, 19th Century,Histories, Nineteenth Century,History, 19th Cent. (Medicine),Nineteenth Century Histories,Nineteenth Century History
D049673	History, 20th Century	Time period from 1901 through 2000 of the common era.	20th Century History,20th Cent. History (Medicine),20th Cent. History of Medicine,20th Cent. Medicine,Historical Events, 20th Century,History of Medicine, 20th Cent.,History, Twentieth Century,Medical History, 20th Cent.,Medicine, 20th Cent.,20th Cent. Histories (Medicine),20th Century Histories,Cent. Histories, 20th (Medicine),Cent. History, 20th (Medicine),Century Histories, 20th,Century Histories, Twentieth,Century History, 20th,Century History, Twentieth,Histories, 20th Cent. (Medicine),Histories, 20th Century,Histories, Twentieth Century,History, 20th Cent. (Medicine),Twentieth Century Histories,Twentieth Century History
D049690	History, Ancient	The period of history before 500 of the common era.	Ancient History,Ancient History (Medicine),Ancient History of Medicine,History of Medicine, Ancient,Medicine, Ancient History,Ancient Histories (Medicine),Ancient History Medicine,Ancient History Medicines,Histories, Ancient (Medicine),History Medicine, Ancient,History Medicines, Ancient,History, Ancient (Medicine),Medicine Ancient History,Medicines, Ancient History