-transparent.png){kind=logo}
In vivo, the polychlorinated biphenyl (PCB) metabolite 4,4'-bis(methylsulphonyl)-2,2',5,5'- tetrachlorobiphenyl--(MeSO2)2TCB--selectively accumulates in the Clara cells of the bronchiolar epithelium and in the secretory contents of the bronchiolar lumen. In vitro characterization of the interaction of tritiated (MeSO2)2TCB with the lung suggests that this selective accumulation is due to the presence of a secreted ([3H]MeSO2)2TCB-binding protein in the respiratory tract of rats, mice and man. The protein appears to be an almost globular, low-molecular-weight acidic protein which binds ([3H]MeSO2)2TCB and certain other methylsulphonyl PCBs with high affinity. Because of the pathway outlined for accumulation, it is suggested that methylsulphonyl PCBs should be included in studies designed to elucidate the mechanism(s) of PCB-induced lung toxicity.
J Lund, and
O Andersson, and
L Poellinger, and
J A Gustafsson
September 1986,
Toxicology letters,
J Lund, and
O Andersson, and
L Poellinger, and
J A Gustafsson
January 1985,
Drug metabolism and disposition: the biological fate of chemicals,
J Lund, and
O Andersson, and
L Poellinger, and
J A Gustafsson
May 1986,
Toxicology and applied pharmacology,
J Lund, and
O Andersson, and
L Poellinger, and
J A Gustafsson
February 1985,
Molecular pharmacology,
J Lund, and
O Andersson, and
L Poellinger, and
J A Gustafsson
November 1984,
Acta pharmacologica et toxicologica,
J Lund, and
O Andersson, and
L Poellinger, and
J A Gustafsson
March 1985,
Carcinogenesis,
J Lund, and
O Andersson, and
L Poellinger, and
J A Gustafsson
May 2011,
Chemical research in toxicology,
J Lund, and
O Andersson, and
L Poellinger, and
J A Gustafsson
December 1979,
Bulletin of environmental contamination and toxicology,
J Lund, and
O Andersson, and
L Poellinger, and
J A Gustafsson
September 1989,
Toxicology and applied pharmacology,
J Lund, and
O Andersson, and
L Poellinger, and
J A Gustafsson
November 1995,
Applied and environmental microbiology,
