Biomaterial Database

Reversibility of urinary tract abnormalities due to Schistosoma haematobium infection. 1986

E Doehring, and J H Ehrich, and H J Bremer

In view of the controversial results regarding reversibility of urinary tract lesions due to Schistosoma haematobium infection, 103 patients in the People's Republic of Congo were followed up one year after treatment with Praziquantel (40 mg/kg body wt) by means of ultrasonography. The study group consisted mainly of children. Before therapy a total of 113 lesions were detected in the lower urinary tract. These consisted of bladder wall enlargements (N = 53), enlargements of the bladder wall in combination with singular (N = 16) or multiple polyps (N = 30), vesical calcifications (N = 10), and cases with cystitis cystica (N = 4). One year after therapy, a drastic reduction of ova output was observed, and only eight pathological abnormalities of the lower urinary tract were still detectable. Vesical calcifications persisted in four out of ten cases. Urinary tract obstructions of different degrees (N = 42) showed a comparably marked reversibility. It was concluded that, in children, the resolution of bladder lesions induced by urinary schistosomiasis resulted in reversibility of urinary tract obstructions one year after treatment with Praziquantel.

UI	MeSH Term	Description	Entries
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D010270	Parasite Egg Count	Determination of parasite eggs in feces.	Count, Parasite Egg,Counts, Parasite Egg,Egg Count, Parasite,Egg Counts, Parasite,Parasite Egg Counts
D011223	Praziquantel	An anthelmintic used in most schistosome and many cestode infestations.	Biltricide,Cesol,Cisticid,Cysticide,Droncit,Drontsit,EMBAY 8440,Prasiquantel,Praziquantel, (+-)-Isomer,Praziquantel, (R)-Isomer,Praziquantel, (S)-Isomer,Pyquiton,Traziquantel
D001743	Urinary Bladder	A musculomembranous sac along the URINARY TRACT. URINE flows from the KIDNEYS into the bladder via the ureters (URETER), and is held there until URINATION.	Bladder,Bladder Detrusor Muscle,Detrusor Urinae,Bladder Detrusor Muscles,Bladder, Urinary,Detrusor Muscle, Bladder,Detrusor Muscles, Bladder
D002648	Child	A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL.	Children
D003223	Congo	A republic in central Africa lying between GABON and DEMOCRATIC REPUBLIC OF THE CONGO and south of Cameroon. Its capital is Brazzaville.	Republic of the Congo,Congo (Brazzaville)
D004341	Drug Evaluation	Any process by which toxicity, metabolism, absorption, elimination, preferred route of administration, safe dosage range, etc., for a drug or group of drugs is determined through clinical assessment in humans or veterinary animals.	Evaluation Studies, Drug,Drug Evaluation Studies,Drug Evaluation Study,Drug Evaluations,Evaluation Study, Drug,Evaluation, Drug,Evaluations, Drug,Studies, Drug Evaluation,Study, Drug Evaluation
D005500	Follow-Up Studies	Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.	Followup Studies,Follow Up Studies,Follow-Up Study,Followup Study,Studies, Follow-Up,Studies, Followup,Study, Follow-Up,Study, Followup
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293	Adolescent	A person 13 to 18 years of age.	Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths